Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2021; 9(20): 5611-5620
Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5611
Low-dose clozapine-related seizure: A case report and literature review
Dan-Sheng Le, Heng Su, Zheng-Luan Liao, En-Yan Yu
Dan-Sheng Le, The Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou 310051, Zhejiang Province, China
Heng Su, Zheng-Luan Liao, Department of Psychiatry, Zhejiang Provincial People’s Hospital, Hangzhou 310000, Zhejiang Province, China
En-Yan Yu, Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, China
Author contributions: Le DS conceived the central idea, analyzed clinical data and wrote the initial draft; all authors participated in clinical diagnosis and revised the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: En-Yan Yu, MM, Chief Physician, Professor, Department of Psychiatry, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, No. 1 East Banshan Road, Gongshu District, Hangzhou 310022, Zhejiang Province, China. yuenyan@aliyun.com
Received: February 8, 2021
Peer-review started: February 8, 2021
First decision: March 27, 2021
Revised: April 7, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: July 16, 2021
Processing time: 148 Days and 16.6 Hours
Core Tip

Core Tip: Clozapine-related seizure is a serious adverse reactions of clozapine, which should be given more attention to its early prevention and optimal treatment. Clinical features, treatment options and factors that may contribute to the development of clozapine-related seizures were summarized through case analysis and literature review, and relevant cases published in the last 20 years were summarized and listed.