Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2021; 9(20): 5514-5525
Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5514
Type 2 diabetes mellitus increases liver transplant-free mortality in patients with cirrhosis: A systematic review and meta-analysis
Zi-Jin Liu, Yi-Jie Yan, Hong-Lei Weng, Hui-Guo Ding
Zi-Jin Liu, Yi-Jie Yan, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You’an Hospital Affiliated to Capital Medical University, Beijing 100069, China
Hong-Lei Weng, Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany
Author contributions: Liu ZJ and Yan YJ searched the literature and collected the data; Liu ZJ wrote the manuscript; Ding HG designed the project and edited the manuscript; Weng HL helped polish the language of the manuscript; all the authors have read and approved the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
PRISMA 2009 Checklist statement: This systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Guo Ding, MD, Chief Doctor, Director, Department of Gastroenterology and Hepatology, Beijing You’an Hospital Affiliated to Capital Medical University, No. 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing 100069, China. dinghuiguo@ccmu.edu.cn
Received: February 9, 2021
Peer-review started: February 9, 2021
First decision: April 19, 2021
Revised: April 27, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: July 16, 2021
Processing time: 147 Days and 22.9 Hours
Core Tip

Core Tip: No consensus is available in the literature about whether type 2 diabetes mellitus (T2DM) can influence the prognosis and complications of liver cirrhosis. This is the first systematic review and meta-analysis comparing the mortality, hepatocellular carcinoma, hepatic encephalopathy, ascites, esophageal varices bleeding, and spontaneous bacterial peritonitis rates between T2DM and non-T2DM cirrhotic patients.