Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2021; 9(20): 5391-5397
Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5391
Published online Jul 16, 2021. doi: 10.12998/wjcc.v9.i20.5391
Detection of short stature homeobox 2 and RAS-associated domain family 1 subtype A DNA methylation in interventional pulmonology
Jian Wu, Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Peng Li, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Li P participated in research design and performance; Wu J and Li P contributed to manuscript writing and revision.
Conflict-of-interest statement: No funding was utilized for this manuscript and the authors have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Li, MD, PhD, Attending Doctor, Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. lipengcmu@163.com
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: April 4, 2021
Revised: April 7, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: July 16, 2021
Processing time: 131 Days and 22.9 Hours
Peer-review started: February 25, 2021
First decision: April 4, 2021
Revised: April 7, 2021
Accepted: May 20, 2021
Article in press: May 20, 2021
Published online: July 16, 2021
Processing time: 131 Days and 22.9 Hours
Core Tip
Core Tip: Lung cancer is the most common cancer in the world. Although the diagnosis and treatment are improved, there are still a large number of cases found with advanced stage when diagnosed. DNA methylation is key to regulate gene expression and maintain cell characteristics. Studies have showed that short stature homeobox 2 (SHOX2) promoter methylation and RAS-associated domain family 1 subtype A (RASSF1A) DNA methylation have been identified as biomarkers for the diagnosis of lung cancer. We review the application of SHOX2 and RASSF1A in interventional pulmonology, and introduce some of our research results in this field.