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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2021; 9(19): 5191-5196
Published online Jul 6, 2021. doi: 10.12998/wjcc.v9.i19.5191
Published online Jul 6, 2021. doi: 10.12998/wjcc.v9.i19.5191
Myelodysplastic syndrome transformed into B-lineage acute lymphoblastic leukemia: A case report
Ye-Jing Zhu, Department of Clinical Medicine, Clinical College of Jining Medical University, Jining 272000, Shandong Province, China
Xiang-Yu Ma, Department of Science and Education, People's Hospital of Rizhao, Rizhao 276800, Shandong Province, China
Yun-Liang Hao, Yun Guan, Department of Hematology, Jining First People’s Hospital, Jining 272000, Shandong Province, China
Author contributions: Zhu YJ, Guan Y, and Ma XY contributed to data curation; Hao YL contributed to project administration; Zhu YJ and Ma XY contributed to resources; Hao YL contributed to fund acquisition; Zhu YJ and Guan Y wrote the first draft and reviewed and edited the manuscript.
Supported by Shandong Medicine and Health Science Technology Development Plan , No. 2017WSA08039 ; Jining Key Research and Development Program , No. 2018SMNS008 ; Doctoral Research Startup Foundation of Jining First People’s Hospital , No. 2019003 ; and TCM Technology Development Plan , No. 20190744 .
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun Guan, PhD, Doctor, Department of Hematology, Jining First People’s Hospital, No. 6 Jiankang Road, Jining 272000, Shandong Province, China.
Received: December 13, 2020
Peer-review started: December 13, 2020
First decision: March 27, 2021
Revised: April 6, 2021
Accepted: May 8, 2021
Article in press: May 8, 2021
Published online: July 6, 2021
Processing time: 188 Days and 21.3 Hours
Peer-review started: December 13, 2020
First decision: March 27, 2021
Revised: April 6, 2021
Accepted: May 8, 2021
Article in press: May 8, 2021
Published online: July 6, 2021
Processing time: 188 Days and 21.3 Hours
Core Tip
Core Tip: We present a case of ring-shaped sideroblastic myelodysplastic syndrome, with refractory hemocytopenia due to multi-lineage dysplasia, that was transformed into B-cell acute lymphoblastic leukemia. Even though the lymphoid progression in myelodysplastic syndrome has been reported previously, most displayed myeloid-lymphoid hybrid, B cell acute lymphoblastic leukemia is rarely reported, and the specific mechanism is still unclear. We report a rare lymphoid transformation in order to provide information for the study of specific mechanism, and help doctors to provide appropriate treatment to patients.