Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2021; 9(18): 4837-4843
Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4837
Central pontine myelinolysis mimicking glioma in diabetes: A case report
Xiao-Yong Shi, Meng-Ting Cai, Hao Shen, Jin-Xia Zhang
Xiao-Yong Shi, Department of Brain Center, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Meng-Ting Cai, Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China
Hao Shen, Department of Neurology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310000, Zhejiang Province, China
Jin-Xia Zhang, Department of Clinical Psychology (Sleep Medical Center), Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Shi XY contributed literature review, initial draft manuscript preparation; Cai MT contributed literature review, initial draft manuscript preparation, provided radiology images; Shen H contributed patient management, provided clinical data; Zhang JX contributed concept and design of the study, final approval of the version to be published; all authors read and approved the final manuscript.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Xia Zhang, MD, Doctor, Department of Clinical Psychology (Sleep Medical Center), Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, No. 1630 Huanding Road, Hangzhou 310000, Zhejiang Province, China. zhangjinxia20000@163.com
Received: February 5, 2021
Peer-review started: February 5, 2021
First decision: March 7, 2021
Revised: March 9, 2021
Accepted: March 31, 2021
Article in press: March 31, 2021
Published online: June 26, 2021
Core Tip

Core Tip: Central pontine myelinolysis (CPM) usually occurs during rapid correction of serum osmolality. We describe a 49-year-old man with type 2 diabetes who developed CPM without a history of hyponatremia or other common causes. Lesions in his brainstem showed atypical glioma-like inhomogeneous signal intensity on contrast-enhanced magnetic resonance imaging. He recovered after methylprednisolone pulse therapy in the acute phase and subsequent dose tapering. Our patient revealed an unusual cause and imaging presentation of CPM, implying the benefits of corticosteroid therapy to outcomes. Thus, it might be helpful for clinicians on diagnostic and therapeutic decision in the future.