Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2021; 9(18): 4520-4541
Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4520
Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer
Teng-Fei Yin, Dong-Yan Zhao, Yuan-Chen Zhou, Qian-Qian Wang, Shu-Kun Yao
Teng-Fei Yin, Yuan-Chen Zhou, Qian-Qian Wang, Shu-Kun Yao, Graduate school, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China
Dong-Yan Zhao, Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Dong-Yan Zhao, Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Author contributions: Yin TF conceived and designed the study, performed formal analysis and prepared the original draft; Zhao DY participated in data analysis and manuscript revision; Zhou YC and Wang QQ reviewed and edited the manuscript critically; Yao SK designed and supervised the study, revised the manuscript, and obtained the funding; all authors read and approved the final manuscript.
Supported by National Key Development Plan for Precision Medicine Research, No. 2017YFC0910002.
Institutional review board statement: This study was approved by the Ethics Committee of China-Japan Friendship Hospital, No. 2018-116-K85-1.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Kun Yao, MD, PhD, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Received: December 11, 2020
Peer-review started: December 11, 2020
First decision: January 17, 2021
Revised: January 26, 2021
Accepted: February 26, 2021
Article in press: February 26, 2021
Published online: June 26, 2021
Core Tip

Core Tip: The biological functions of circRNA and miRNA interactions and their potential as noninvasive biomarkers have not been well elucidated in colorectal cancer (CRC). In this study, we constructed a circRNA-miRNA-mRNA regulatory network with 19 circRNAs, 13 miRNAs and 28 mRNAs. GO and KEGG analyses indicated several signaling pathways probably involved in tumorigenesis. After being combined with survival analysis, a prognostic subnetwork was constructed including 5 circRNAs, 3 miRNAs and 3 mRNAs, which may represent novel diagnostic and prognostic candidate biomarkers, as well as therapeutic targets of CRC.