Randomized Clinical Trial
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2021; 9(16): 3895-3907
Published online Jun 6, 2021. doi: 10.12998/wjcc.v9.i16.3895
Comparison of white-light endoscopy, optical-enhanced and acetic-acid magnifying endoscopy for detecting gastric intestinal metaplasia: A randomized trial
Ying-Hao Song, Li-Dong Xu, Meng-Xuan Xing, Kun-Kun Li, Xing-Guo Xiao, Yong Zhang, Lu Li, Yan-Jing Xiao, Yu-Lei Qu, Hui-Li Wu
Ying-Hao Song, Meng-Xuan Xing, Xinxiang Medical University, Xinxiang 453000, Henan Province, China
Ying-Hao Song, Li-Dong Xu, Meng-Xuan Xing, Kun-Kun Li, Xing-Guo Xiao, Yong Zhang, Lu Li, Hui-Li Wu, Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, Henan Province, China
Yan-Jing Xiao, Department of Pathology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450000, Henan Province, China
Yu-Lei Qu, Department of Gastroenterology, People's Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan Province, China
Author contributions: Song YH, Xu LD, Qu YL and Xing MX were responsible for the study conception and design, data analysis and interpretation, and manuscript drafting; Li KK, Xiao XG, Zhang Y, Xiao YJ and Wu HL critically revised the article for important intellectual content; all the authors reviewed and approved the final version to be published. In addition, Ying-Hao Song wishes to thank Yu-Lei Qu for her patience, care and support over the past years. Will you marry me?
Supported by Key Project of Science and Technology of Henan, No. 202102310382.
Institutional review board statement: The research protocol was approved by the Ethics Committee of Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 202031.
Clinical trial registration statement: This study was registered at chictr.org.cn. The registration identification number is ChiCTR2000032072.
Informed consent statement: All participating patients provided written informed consent.
Conflict-of-interest statement: All authors declare no potential conflicting interests related to this paper.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Li Wu, MD, Chief Doctor, Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 16 North Tongbai Road, Zhongyuan District, Zhengzhou 450000, Henan Province, China. wuhuili660912@126.com
Received: November 6, 2020
Peer-review started: November 6, 2020
First decision: January 23, 2021
Revised: January 31, 2021
Accepted: February 25, 2021
Article in press: February 25, 2021
Published online: June 6, 2021
Processing time: 189 Days and 3.8 Hours
Core Tip

Core Tip: This study evaluated the diagnostic value of optical-enhanced magnifying endoscopy (ME-OE) for gastric intestinal metaplasia. By comparing ME-OE with existing magnifying endoscopy techniques, the study evaluated their diagnostic ability, operating time, and inter- and intra-observer agreements. Our study showed that ME-OE is an efficient, convenient, and time-saving endoscopic technique for endoscopists, especially experienced endoscopists. We recommend its wide clinical application in diagnosing gastric intestinal metaplasia.