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World J Clin Cases. May 26, 2021; 9(15): 3506-3516
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3506
Association of hidradenitis suppurativa with Crohn’s disease
Meng Zhang, Qun-De Chen, Hai-Xia Xu, Yu-Meng Xu, Hong-Jin Chen, Bo-Lin Yang
Meng Zhang, Qun-De Chen, Hai-Xia Xu, Yu-Meng Xu, Bo-Lin Yang, Department of Colorectal Surgery, TheAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Hong-Jin Chen, First Clinical Medical College, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Author contributions: Zhang M contributed to literature search, data extraction and interpretation, and drafting of the manuscript; Chen QD contributed to literature search and data extraction and interpretation; Xu YM and Xu HX contributed to initial revision of the manuscript; Chen HJ contributed to critical revision of the manuscript for important intellectual content; Yang BL contributed to concept and design, funding, literature search, data extraction and interpretation, and critical revision of the manuscript for important intellectual content; all authors have read and approved the manuscript.
Supported by The Open Projects of the Discipline of Nanjing University of Chinese Medicine Supported by Academic Priority Discipline of Jiangsu Higher Education Institutions, 333 Project of Jiangsu Province, China, No. LGY2019069.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bo-Lin Yang, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. blyang1971@163.com
Received: January 19, 2021
Peer-review started: January 19, 2021
First decision: February 9, 2021
Revised: February 21, 2021
Accepted: March 17, 2021
Article in press: March 17, 2021
Published online: May 26, 2021
Processing time: 111 Days and 20.2 Hours
Core Tip

Core Tip: In this review, we summarize the recent studies on the association between hidradenitis suppurativa and Crohn's disease, based on clinical and histological similarities (sinus tract development, granulomatous inflammation, and scarring), intersections in pathogenesis (genetic loci, immune dysregulation mechanisms, and microbiome changes), and commonality in treatment.