Zhang M, Chen QD, Xu HX, Xu YM, Chen HJ, Yang BL. Association of hidradenitis suppurativa with Crohn’s disease. World J Clin Cases 2021; 9(15): 3506-3516 [PMID: 34046451 DOI: 10.12998/wjcc.v9.i15.3506]
Corresponding Author of This Article
Bo-Lin Yang, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. blyang1971@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Meng Zhang, Qun-De Chen, Hai-Xia Xu, Yu-Meng Xu, Bo-Lin Yang, Department of Colorectal Surgery, TheAffiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Hong-Jin Chen, First Clinical Medical College, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Author contributions: Zhang M contributed to literature search, data extraction and interpretation, and drafting of the manuscript; Chen QD contributed to literature search and data extraction and interpretation; Xu YM and Xu HX contributed to initial revision of the manuscript; Chen HJ contributed to critical revision of the manuscript for important intellectual content; Yang BL contributed to concept and design, funding, literature search, data extraction and interpretation, and critical revision of the manuscript for important intellectual content; all authors have read and approved the manuscript.
Supported byThe Open Projects of the Discipline of Nanjing University of Chinese Medicine Supported by Academic Priority Discipline of Jiangsu Higher Education Institutions, 333 Project of Jiangsu Province, China, No. LGY2019069.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bo-Lin Yang, MD, Chief Doctor, Professor, Surgeon, Department of Colorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. blyang1971@163.com
Received: January 19, 2021 Peer-review started: January 19, 2021 First decision: February 9, 2021 Revised: February 21, 2021 Accepted: March 17, 2021 Article in press: March 17, 2021 Published online: May 26, 2021 Processing time: 111 Days and 20.2 Hours
Abstract
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder characterized by recurrent nodules, abscesses, and sinus tracts. Crohn’s disease (CD) is characterized by inflammation of the entire digestive tract and belongs to the group of inflammatory bowel diseases, and there are many extraintestinal manifestations, among which hidradenitis suppurativa is one of the rare extraintestinal manifestations. There appears to be a strong association between CD and HS based on clinical and histological similarities (sinus tract development, granulomatous inflammation, and scarring), intersections in pathogenesis (genetic loci, immune dysregulation mechanisms, and microbiome changes), and commonality in treatment. In this review, we summarize recent studies on the association between HS and CD.
Core Tip: In this review, we summarize the recent studies on the association between hidradenitis suppurativa and Crohn's disease, based on clinical and histological similarities (sinus tract development, granulomatous inflammation, and scarring), intersections in pathogenesis (genetic loci, immune dysregulation mechanisms, and microbiome changes), and commonality in treatment.
