Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2021; 9(14): 3478-3486
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3478
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3478
Paget’s disease of bone: Report of 11 cases
Xin-Yu Miao, Xian-Ling Wang, Zhao-Hui Lyu, Jian-Ming Ba, Yu Pei, Jing-Tao Dou, Wei-Jun Gu, Jin Du, Qing-Hua Guo, Kang Chen, Yi-Ming Mu, Department of Endocrinology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
Xin-Yu Miao, Department of Endocrinology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Miao XY, Wang XL, and Pei Y prepared and collected the case data; Mu YM, Lyu ZH, Ba JM, Dou JT, Gu WJ, Du J, Guo QH, and Chen K analyzed the diagnosis and treatment of the case, and summarized the experience of diagnosis and treatment; Miao XY and Wang XL reviewed the literature and was responsible for drafting the manuscript; all authors gave final approval for the version to be submitted.
Supported by Special Scientific Research Project of Military Healthcare , No. 19BJZ29 ; Beijing Haidian District Health Development Research and Cultivation Program , No. HP-2021-03-80303 .
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-Ling Wang, MD, PhD, Chief Doctor, Department of Endocrinology, The First Medical Center, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. wangxianling1972@sohu.com
Received: December 30, 2020
Peer-review started: December 30, 2020
First decision: January 24, 2021
Revised: February 2, 2021
Accepted: March 3, 2021
Article in press: March 3, 2021
Published online: May 16, 2021
Peer-review started: December 30, 2020
First decision: January 24, 2021
Revised: February 2, 2021
Accepted: March 3, 2021
Article in press: March 3, 2021
Published online: May 16, 2021
Core Tip
Core Tip: Paget’s disease of bone (PDB) is a rare metabolic bone disease in China that has high missed diagnosis and misdiagnosis rates. We retrospectively summarize the clinical data of 11 patients with a diagnosis of PDB to provide additional clinical evidence for the disease. We found that PDB presented with a predisposition toward the older male population, and the main clinical symptoms were bone pain, deformity, and a high risk of disability. Early identification of PDB can be made through elevated alkaline phosphatase levels and typical presentations on bone X-ray and from bone tissue biopsy. Bisphosphonates are the first choice to improve the symptoms and prognosis.