Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2021; 9(14): 3403-3410
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3403
Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of the literature
Wei Zheng, Qiao-Qiao Yin, Tian-Chen Hui, Wen-Hao Wu, Qing-Qing Wu, Hai-Jun Huang, Mei-Juan Chen, Rong Yan, Yi-Cheng Huang, Hong-Ying Pan
Wei Zheng, Qiao-Qiao Yin, Hai-Jun Huang, Mei-Juan Chen, Rong Yan, Yi-Cheng Huang, Hong-Ying Pan, Department of Infectious Diseases, Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Tian-Chen Hui, The Graduate School, Bengbu Medical College, Bengbu 233030, Anhui Province, China
Wen-Hao Wu, The Graduate School, Qingdao University, Qingdao 266071, Shandong Province, China
Qing-Qing Wu, The Second School of Clinical Medicine, Zhejiang Chinese Medicinal University, Hangzhou 310053, Zhejiang Province, China
Author contributions: Zheng W designed the report and wrote the paper; Hui TC, Wu WH, and Wu QQ collected the patient’s clinical data; Huang YC, Yan Y, Yin QQ, and Chen MJ analyzed the data; Huang HJ and Pan HY revised the paper; all authors have read and approved the final version of this manuscript.
Supported by National Science and Technology Major Subproject of China, No. 2018ZX10302205-002; Chinese Foundation for Hepatitis Prevention and Control-Tianqing Liver Disease Research Fund Subject, No. TQGB2020168.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong-Ying Pan, MD, Doctor, Department of Infectious Diseases, Zhejiang Provincial People’s Hospital People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. hypanhz@139.com
Received: November 19, 2020
Peer-review started: November 19, 2020
First decision: February 12, 2021
Revised: February 22, 2021
Accepted: March 5, 2021
Article in press: March 5, 2021
Published online: May 16, 2021
Processing time: 160 Days and 18.3 Hours
Core Tip

Core Tip: Primary bone lymphoma (PBL) is an uncommon extranodal disease that represents approximately 1%-3% of lymphomas. Among PBLs, diffuse large B-cell lymphoma is the most common pathological type, accounting for approximately 70%-80% of all PBLs. The anaplastic large-cell lymphoma (ALCL) subtype of PBL is extremely rare, and it therefore remains unclear whether it is similar to ALCL in general or whether it is a subtype with unique clinical biological characteristics. Furthermore, the prognostic impact of anaplastic lymphoma kinase (ALK) expression in ALCL with primary bone lesions is still under debate. Herein, we report one rare case of primary bone ALK positive ALCL in a 66-year-old man. Our case suggests that physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement, and lymphoma should be considered in the differential diagnosis of primary bone lesions.