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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2021; 9(14): 3350-3355
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3350
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3350
Novel intergenic KIF5B-MET fusion variant in a patient with gastric cancer: A case report
Zhi-Wei Wu, Qing Chen, Juan Hou, Yan Sun, Wang-Kun Lu, Li-Jiang Yu, Department of Oncology, The Seventh Affiliated Hospital of Yangzhou University, Jingjiang People's Hospital, Jingjiang 214500, Jiangsu Province, China
Yu Sha, Jing Chen, Department of Pathology, The Seventh Affiliated Hospital of Yangzhou University, Jingjiang People's Hospital, Jingjiang 214500, Jiangsu Province, China
Author contributions: Yu LJ and Wu ZW designed the study; Wu ZW, Chen Q, and Hou J drafted the manuscript; Sha Y and Chen J conducted the histological and immunohistochemical evaluations; Sha Y and Lu WK performed the NGS analysis; all authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of his clinical details and clinical images in this case report.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Jiang Yu, BMed, Chief Physician, Department of Oncology, The Seventh Affiliated Hospital of Yangzhou University, Jingjiang People's Hospital, No. 28 Zhongzhou Road, Jingjiang 214500, Jiangsu Province, China. yulijiang830@163.com
Received: November 25, 2020
Peer-review started: November 25, 2020
First decision: January 7, 2021
Revised: January 20, 2021
Accepted: March 3, 2021
Article in press: March 3, 2021
Published online: May 16, 2021
Peer-review started: November 25, 2020
First decision: January 7, 2021
Revised: January 20, 2021
Accepted: March 3, 2021
Article in press: March 3, 2021
Published online: May 16, 2021
Core Tip
Core Tip: In this case report, we report the discovery of a "tumor within a tumor " in the lung tumor tissue of a 64-year-old non-smoking male patient. Combined with the medical history and the results of enzyme labeling, the focal area of the postoperative pathology was considered to be gastric cancer. To seek potential therapeutic regimens, an intergenic region between KIF5B and MET fusion was identified, which contains a MET kinase domain and a coil curl domain encoded by KIF5B exons 1-25, which may drive the tumorigenesis.