Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 16, 2021; 9(14): 3308-3319
Published online May 16, 2021. doi: 10.12998/wjcc.v9.i14.3308
Comparison of smear cytology with liquid-based cytology in pancreatic lesions: A systematic review and meta-analysis
Xiao-Hui Zhang, Shi-Yang Ma, Na Liu, Zhong-Cao Wei, Xu Gao, Yu-Jie Hao, Yi-Xin Liu, Ya-Qin Cai, Jin-Hai Wang
Xiao-Hui Zhang, Shi-Yang Ma, Na Liu, Zhong-Cao Wei, Xu Gao, Yu-Jie Hao, Yi-Xin Liu, Ya-Qin Cai, Jin-Hai Wang, Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China
Author contributions: Zhang XH and Wang JH designed the research study; Zhang XH and Wei ZC screened the articles and extracted the data; Zhang XH, Liu YX, and Cai YQ compiled the tables and figures; Zhang XH, Gao X, and Hao YJ analyzed the data; Zhang XH wrote the manuscript; Ma SY and Liu N critically modified the content of the article; All authors have read and approve the final manuscript.
Conflict-of-interest statement: No potential conflicts of interest exist.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jin-Hai Wang, MD, Doctor, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 West Fifth Road, Xi'an 710004, Shaanxi Province, China. jinhaiwang@hotmail.com
Received: November 12, 2020
Peer-review started: November 12, 2020
First decision: January 23, 2021
Revised: January 30, 2021
Accepted: March 10, 2021
Article in press: March 10, 2021
Published online: May 16, 2021
Core Tip

Core Tip: Numerous studies comparing the diagnostic efficacy of smear cytology and liquid-based cytology (LBC) for endoscopic ultrasonography-guided fine-needle aspiration in pancreatic lesions yielded mixed results. Therefore, we conducted this systematic review and meta-analysis, finding that for endoscopic ultrasonography-guided fine-needle aspiration in pancreatic lesions (particularly solid lesions), smear cytology with Rapid On-Site Evaluation represents a superior diagnostic technique. If Rapid On-Site Evaluation is unavailable, LBC may replace smears. The diagnostic accuracy of LBC depends on different LBC techniques.