Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2021; 9(12): 2899-2907
Published online Apr 26, 2021. doi: 10.12998/wjcc.v9.i12.2899
Published online Apr 26, 2021. doi: 10.12998/wjcc.v9.i12.2899
Torsades de pointes episode in a woman with high-grade fever and inflammatory activation: A case report
Hui Qiu, Hong-Wei Li, Wei-Ping Li, Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Shu-Hong Zhang, Xiao-Ge Zhou, Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Li WP and Qiu H conceived and designed the study; Qiu H was involved in data collection and analysis and drafting the article; Li HW participated in performance of the research; Zhang SH and Zhou XG performed the pathologic analyses and interpretation; Li WP revised the paper and had primary responsibility for final content; all authors issued final approval for the version to be submitted.
Supported by the Beijing Key Clinical Subject Program and Beijing Municipal Administration of Hospitals Incubating Program , No. PX2018002 .
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Ping Li, MD, PhD, Chief Doctor, Professor, Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing 100050, China. xueer09@163.com
Received: January 1, 2021
Peer-review started: January 1, 2021
First decision: January 24, 2021
Revised: February 7, 2021
Accepted: February 24, 2021
Article in press: February 24, 2021
Published online: April 26, 2021
Processing time: 103 Days and 18.9 Hours
Peer-review started: January 1, 2021
First decision: January 24, 2021
Revised: February 7, 2021
Accepted: February 24, 2021
Article in press: February 24, 2021
Published online: April 26, 2021
Processing time: 103 Days and 18.9 Hours
Core Tip
Core Tip: Torsades de pointes (TdP) is a life-threatening arrhythmia and may be caused by congenital long QT syndrome (cLQTS) or acquired LQTS (aLQTS). Meanwhile, aLQTS may share a similar genetic background with cLQTS. Here, we present a case of TdP episode during the combination of antibiotics for high-grade fever of unexplained origin before a confirmed diagnosis of adult-onset Still’s disease (AOSD). This case study highlights the importance of early diagnosis of AOSD, the key role of systemic inflammatory activation, and the risk of antibiotic-induced TdP/LQTS onset. Genetic analysis should be considered to identify individuals at high risk of developing TdP.