Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2021; 9(12): 2890-2898
Published online Apr 26, 2021. doi: 10.12998/wjcc.v9.i12.2890
Timing of convalescent plasma therapy-tips from curing a 100-year-old COVID-19 patient using convalescent plasma treatment: A case report
Bo Liu, Kang-Kang Ren, Nian Wang, Xin-Ping Xu, Jue Wu
Bo Liu, Department of Laboratory, Hospital No. 967 of PLA, Dalian 116000, Liaoning Province, China
Bo Liu, Department of Laboratory, Guanggu Branch of Hubei Maternal and Child Health Hospital, Wuhan 430073, Hubei Province, China
Kang-Kang Ren, Xin-Ping Xu, Gaoxin Hospital, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Nian Wang, GrandOmics Diagnostics Co., Ltd, Wuhan 430073, Hubei Province, China
Jue Wu, Translational Medicine Research Center, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Liu B collected the data for the case presentation and contributed to manuscript drafting; Wu J and Wang N contributed to supervision of the data collection, analysis of the data, and write-up of this manuscript; Ren KK and Xu XP contributed to the data analysis; All authors contributed to the critical review and final approval of the manuscript.
Supported by Medical Collaborative Science and Technology Innovation Research Project of Science and Technology Commission of Beijing, No. Z181100001918013; and Nanchang Science and Technology Bureau, No. 20203306.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jue Wu, PhD, Chief Physician, Translational Medicine Research Center, Medical Innovation Research Division of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. juetwmj79347@163.com
Received: December 5, 2020
Peer-review started: December 5, 2020
First decision: January 7, 2021
Revised: January 18, 2021
Accepted: March 3, 2021
Article in press: March 3, 2021
Published online: April 26, 2021
Processing time: 130 Days and 12.3 Hours
Core Tip

Core Tip: A 100-year-old coronavirus disease 2019 (COVID-19) patient with several underlying diseases including hypertension (stage 2 hypertension) accompanied by chronic obstructive pulmonary disease and emphysema was treated using convalescent plasma. Besides the effective maintenance of supportive treatment and no antiviral and antibiotic treatment, the convalescent plasma was infused into the patient in the early stage of the infection. This choice of time points (days 7 and 11 of hospitalization) provides a reference for choosing the best timing of convalescent plasma treatment and highlights the effectiveness of the clinical strategy of plasma treatment in the recovery period of patients with COVID-19 pneumonia.