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World J Clin Cases. Apr 26, 2020; 8(8): 1400-1413
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1400
Status, challenges, and future prospects of stem cell therapy in pelvic floor disorders
Juan Cheng, Zhi-Wei Zhao, Ji-Rui Wen, Ling Wang, Li-Wei Huang, Yan-Lin Yang, Feng-Nian Zhao, Jing-Yue Xiao, Fei Fang, Jiang Wu, Ya-Li Miao
Juan Cheng, Ya-Li Miao, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, West China Campus, Sichuan University, Chengdu 610041, Sichuan Province, China
Juan Cheng, Ling Wang, Jiang Wu, Deep Underground Space Medical Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Zhi-Wei Zhao, Ji-Rui Wen, Jing-Yue Xiao, Fei Fang, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Li-Wei Huang, West China School of Stomatology Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Yan-Lin Yang, Feng-Nian Zhao, West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Cheng J, Zhao ZW, Wen JR, Wang L, Huang LW, and Miao YL designed the research; Cheng J, Zhao ZW, Yang YL, Zhao FN, Xiao JY, Fang F, and Wu J analyzed the data; Cheng J, Wen JR, Wang L, Huang LW, Yang YL, Zhao FN, and Xiao JY made critical revisions to the manuscript; Cheng J, Zhao ZW, and Wen JR wrote the paper; Cheng J, Zhao ZW, Wen JR, Wang L, Huang LW, Yang YL, Zhao FN, Xiao JY, Fang F, Wu J, and Miao YL provided the final approval of the version to be published.
Supported by Foundation of Sichuan Provincial Science and Technology Program, No. 2019YFH0147 and No. 2019YFH0158; Chengdu Technological Innovation Research and Development Project, No. 2018-YF05-00195-SN; West China Second University Hospital Xinya Fund, No. kx111; and 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, No. ZYJC18016.
Conflict-of-interest statement: The authors report no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ya-Li Miao, MD, PhD, Chief Doctor, Professor, Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second University Hospital, West China Campus, Sichuan University, No. 17, Renmin South Road, Chengdu 610041, Sichuan Province, China. miaoyali2006@163.com
Received: December 31, 2019
Peer-review started: December 31, 2019
First decision: February 20, 2020
Revised: March 30, 2020
Accepted: April 8, 2020
Article in press: April 8, 2020
Published online: April 26, 2020
Processing time: 115 Days and 6.8 Hours
Core Tip

Core tip: Recently, various studies using different autologous mesenchymal stem cells (MSCs) have achieved promising results showing that: (1) MSCs can undergo transdifferentiation into different cell types of the pelvic floor tissues and improve collagen secretion and neovascularization with induction by a series of cytokines; and (2) MSCs can deliver bioactive molecules to the site of injury to promote angiogenesis by enhancing the migration and proliferation of tissue-specific progenitor cells and inhibiting apoptosis and fibrosis through promoting tissue cell proliferation and collagen synthesis, and inhibiting inflammation by recruiting macrophages and leukocytes, thus improving the connective or neuromuscular tissues in pelvic floor disorders.