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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2020; 8(8): 1385-1390
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1385
Published online Apr 26, 2020. doi: 10.12998/wjcc.v8.i8.1385
Hypertransaminasemia in the course of infection with SARS-CoV-2: Incidence and pathogenetic hypothesis
Maddalena Zippi, Giuseppe Occhigrossi, Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Rome 00157, Italy
Sirio Fiorino, Unit of Internal Medicine, Maggiore Hospital, Local Health Unit of Bologna, Bologna 40133, Italy
Wandong Hong, Department of Gastroenterology and Hepatology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Zippi M and Occhigrossi G made substantial contribution to study conception and design; Fiorino S and Hong W were involved in acquisition, analysis and interpretation of data; Zippi M and Hong W were involved in drafting the article, revising it critically for important intellectual content and gave final approval of the version to be published.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Maddalena Zippi, PhD, Doctor, Medical Assistant, Unit of Gastroenterology and Digestive Endoscopy, Sandro Pertini Hospital, Via dei Monti Tiburtini 385, Rome 00157, Italy. maddyzip@yahoo.it
Received: March 25, 2020
Peer-review started: March 25, 2020
First decision: April 7, 2020
Revised: April 8, 2020
Accepted: April 11, 2020
Article in press: April 11, 2020
Published online: April 26, 2020
Processing time: 29 Days and 16.8 Hours
Peer-review started: March 25, 2020
First decision: April 7, 2020
Revised: April 8, 2020
Accepted: April 11, 2020
Article in press: April 11, 2020
Published online: April 26, 2020
Processing time: 29 Days and 16.8 Hours
Core Tip
Core tip: Severe acute respiratory syndrome coronavirus 2 infection currently represents an emerging pandemic. More and more published papers, with constantly updated data, highlight a concomitant hepatic impairment, particularly, an hypertransaminasemia. In this mini-review, we will try to analyze the incidence and pathogenetic hypothesis of this phenomenon using the currently available data.