Clinical and Translational Research
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2020; 8(5): 854-863
Published online Mar 6, 2020. doi: 10.12998/wjcc.v8.i5.854
Repair mechanism of astrocytes and non-astrocytes in spinal cord injury
Xiang-Yun Liu, Jian-Wei Guo, Jian-Qiang Kou, Yuan-Liang Sun, Xiu-Jun Zheng
Xiang-Yun Liu, Jian-Wei Guo, Jian-Qiang Kou, Yuan-Liang Sun, Xiu-Jun Zheng, Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Zheng XJ and Liu XY designed the research; Guo JW and Kou JQ performed the research; Sun YL and Zheng XJ analyzed the data and wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Affiliated Hospital of Qingdao University Ethics Committee.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiu-Jun Zheng, PhD, Chief Physician, Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, No.16, Jiangsu Road, Qingdao 266003, Shandong Province, China. xiyi5148141@163.com
Received: November 22, 2019
Peer-review started: November 22, 2019
First decision: December 23, 2019
Revised: December 30, 2019
Accepted: February 10, 2020
Article in press: February 10, 2020
Published online: March 6, 2020
Processing time: 101 Days and 8.4 Hours
Core Tip

Core tip: The present study uncovered a co-expression network of key genes involved in astrocyte and non-astrocyte regulation in spinal cord injury. These findings helped to reveal the core dysfunction modules, potential regulatory factors and driving genes of the disease, and to improve our understanding of its pathogenesis.