Clinical and Translational Research
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2020; 8(5): 854-863
Published online Mar 6, 2020. doi: 10.12998/wjcc.v8.i5.854
Repair mechanism of astrocytes and non-astrocytes in spinal cord injury
Xiang-Yun Liu, Jian-Wei Guo, Jian-Qiang Kou, Yuan-Liang Sun, Xiu-Jun Zheng
Xiang-Yun Liu, Jian-Wei Guo, Jian-Qiang Kou, Yuan-Liang Sun, Xiu-Jun Zheng, Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong Province, China
Author contributions: Zheng XJ and Liu XY designed the research; Guo JW and Kou JQ performed the research; Sun YL and Zheng XJ analyzed the data and wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Affiliated Hospital of Qingdao University Ethics Committee.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Xiu-Jun Zheng, PhD, Chief Physician, Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, No.16, Jiangsu Road, Qingdao 266003, Shandong Province, China.
Received: November 22, 2019
Peer-review started: November 22, 2019
First decision: December 23, 2019
Revised: December 30, 2019
Accepted: February 10, 2020
Article in press: February 10, 2020
Published online: March 6, 2020
Research background

Astrocytes are key regulators of inflammatory responses within the central nervous system following spinal cord injury (SCI).

Research motivation

The role and mechanism of astrocytes expression and its function in SCI are still unknown.

Research objectives

The aim of this study was to investigate the effect of astrocytes and non-astrocytes on SCI and to determine the mechanism of action in SCI repair.

Research methods

To identify the core genes that effected SCI at the molecular level using bioinformatics methods.

Research results

Among the four groups of differential results, miR-494, XIST and other core genes were found following further analysis.

Research conclusions

Our findings suggest a role for key genes and potential regulatory factors in regulating core dysfunction mechanisms following SCI.

Research perspectives

The key genes and potential regulatory factors play an important role in the occurrence and development of SCI. Significant genes in neurological tissue repair will be further discussed in future studies.