Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2020; 8(24): 6524-6528
Published online Dec 26, 2020. doi: 10.12998/wjcc.v8.i24.6524
Idiopathic adulthood ductopenia with elevated transaminase only: A case report
Xiao-Chen Zhang, Di Wang, Xiang Li, Yu-Lin Hu, Chong Wang
Xiao-Chen Zhang, Di Wang, Xiang Li, Yu-Lin Hu, Chong Wang, Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Zhang XC was the patient’s doctor in charge and was responsible for collecting medical history, reviewing the literature, and drafting the paper; Wang D and Li X were responsible for collecting medical history; Hu YL was the patient’s doctor in charge; Wang C was the patient’s doctor in charge, reviewed the literature and contributed to manuscript revision; All authors gave final approval for the version to be submitted.
Informed consent statement: Informed consent was obtained from the patient in this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chong Wang, MD, PhD, Attending Doctor, Department of Hepatology, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. wangchong206@sina.com
Received: September 25, 2020
Peer-review started: September 25, 2020
First decision: October 18, 2020
Revised: October 26, 2020
Accepted: November 2, 2020
Article in press: November 2, 2020
Published online: December 26, 2020
Processing time: 85 Days and 8.1 Hours
Core Tip

Core Tip: Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease that has unclear etiology, usually manifested as cholestasis. We report a case with no cholestasis or obvious clinical symptoms, only an increase in transaminases. The diagnosis of IAD relies on liver tissue biopsy. However, this examination is invasive and thus not acceptable by all patients. Therefore, in the clinical diagnostic process, many cases of unexplained liver damage and jaundice are missed. Furthermore, this case proved that the application of ursodeoxycholic acid has an obvious positive effect in the treatment of IAD.