Li J, Zhang R, Gu F, Liu ZL, Sun P. Optical coherence tomography angiography characteristics in Waldenström macroglobulinemia retinopathy: A case report. World J Clin Cases 2020; 8(23): 6071-6079 [PMID: 33344607 DOI: 10.12998/wjcc.v8.i23.6071]
Corresponding Author of This Article
Peng Sun, MD, PhD, Doctor, Department of Ophthalmology, The First Hospital of China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. pengsun.cmu@protonmail.com
Research Domain of This Article
Ophthalmology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2020; 8(23): 6071-6079 Published online Dec 6, 2020. doi: 10.12998/wjcc.v8.i23.6071
Optical coherence tomography angiography characteristics in Waldenström macroglobulinemia retinopathy: A case report
Jun Li, Rui Zhang, Feng Gu, Zhe-Li Liu, Peng Sun
Jun Li, Feng Gu, Zhe-Li Liu, Peng Sun, Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Rui Zhang, Department of Hematology, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Li J and Sun P carried out the studies, collected the clinical data, and drafted the manuscript; Gu F and Liu ZL participated in the data analysis; Sun P and Zhang R diagnosed and treated the patient; all authors read and approved the final manuscript.
Supported bythe National Youth Top-notch Talent of Ten Thousand Talent Program, No. 89602300.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Peng Sun, MD, PhD, Doctor, Department of Ophthalmology, The First Hospital of China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. pengsun.cmu@protonmail.com
Received: May 28, 2020 Peer-review started: May 28, 2020 First decision: September 24, 2020 Revised: October 11, 2020 Accepted: October 26, 2020 Article in press: October 26, 2020 Published online: December 6, 2020 Processing time: 189 Days and 18.7 Hours
Core Tip
Core Tip: Waldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M monoclonal protein, which can be associated with impressive hyperviscosity retinopathy and a unique tendency to develop serous macular detachments. Optical coherence tomography angiography (OCTA) is a new, non-invasive imaging system, providing both structural and blood flow information in the eye. This technique might be of great value for diagnosing or following patients with retinal vascular diseases such as WM retinopathy, especially for those who could not be performed for fluorescein angiography. Here, we report a case of WM retinopathy in both eyes who was treated with intravitreal ranibizumab injection combined with systemic plasmapheresis and chemotherapy. Also, we describe the defining OCTA features associated with WM which have not been reported before.
