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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2020; 8(22): 5663-5669
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5663
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5663
Oral granuloma in a pediatric patient with chronic graft-versus-host disease: A case report
Atsushi Uesugi, Fumihiko Tsushima, Takeshi Kuroshima, Jinkyo Sakurai, Hiroyuki Harada, Oral and Maxillofacial Surgery, Tokyo Medical and Dental University, Tokyo 113-8549, Japan
Makoto Kodama, Human Pathology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Author contributions: Atsushi U, Kuroshima T, and Tsushima F were the patient’s oral and maxillofacial surgeons, reviewed the literature, and contributed to manuscript drafting; Sakurai J and Harada H were the patient’s oral and maxillofacial surgeons, reviewed the literature, and drafted the manuscript; Kodama M performed pathological analysis, reviewed the literature, and drafted the manuscript. All authors issued final approval for the version to be submitted.
Informed consent statement: The authors got informed consent from the patient's family.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016) and have prepared and revised the manuscript according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Atsushi Uesugi, DDS, PhD, Medical Assistant, Oral and Maxillofacial Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. uesugi.atsushi@tokushima-u.ac.jp
Received: June 9, 2020
Peer-review started: June 9, 2020
First decision: September 24, 2020
Revised: October 4, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: November 26, 2020
Processing time: 161 Days and 8.4 Hours
Peer-review started: June 9, 2020
First decision: September 24, 2020
Revised: October 4, 2020
Accepted: October 26, 2020
Article in press: October 26, 2020
Published online: November 26, 2020
Processing time: 161 Days and 8.4 Hours
Core Tip
Core Tip: Oral mucositis is often observed with graft-versus-host disease (GVHD); however, the presence of oral granuloma is rare. This case is the youngest pediatric patient with granuloma associated with GVHD. At the age of 5 mo, she was diagnosed with primary immunodeficiency disease. After transplantation, she developed GVHD and oral mucositis. Notably, nodules appeared on the lip and buccal mucosa, which spontaneously disappeared. Then, a new nodule appeared on the tongue. Histopathological diagnosis was granuloma. It is important to distinguish rapidly grown granulomatous nodules from malignant tumors.