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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2020; 8(22): 5535-5546
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5535
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5535
High serum lactate dehydrogenase and dyspnea: Positive predictors of adverse outcome in critical COVID-19 patients in Yichang
Xiao-Ting Lv, Yong-Xu Jin, Hai-Bo Ding, Cai-Yun Wang, Gong-Ping Chen, Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Xiao-Ting Lv, Institute of Respiratory Disease, Fujian Medical University, Fuzhou 350005, Fujian Province, China
Yong-Ping Zhu, Department of Cardiovascular Surgery, Fujian Medical University Attached Union Hospital, Fuzhou 350001, Fujian Province, China
Ai-Guo Cheng, Department of Critical Medicine, the Third People's Hospital of Yichang, Yichang 443000, Hubei Province, China
Shu-Yu Zhang, Qing-Quan Chen, Department of Laboratory Medicine, Fujian Medical University, Fuzhou 350004, Fujian Province, China
Qi-Cai Liu, Department of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Author contributions: Lv XT, Zhu YP, Chen GP and Liu QC contributed equally to this work; Chen GP, Chen QQ, and Liu QC designed the research study; Cheng AG, Jin YX, Ding HB, Wang CY and Zhang SY performed the research; Cheng AG, Jin YX, Ding HB and Lv XT contributed reagents and analytic tools; Lv XT and Zhu YP analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China , No. 81800070 ; Development Fund Program of Fujian Provincial Health and Family Planning Commission , China, No. 2017-1-43 .
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Fujian Medical University [(No. (2020) 153)].
Informed consent statement: Patients were not required to give informed consent to the study as the analysis used anonymous clinical data that were obtained after each patient gave their informed verbal consent prior to study inclusion.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qi-Cai Liu, MD, Chief Technician, Doctor, Teacher, Department of Reproductive Medicine Centre, First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, Fujian Province, China.
Received: April 26, 2020
Peer-review started: April 26, 2020
First decision: August 23, 2020
Revised: September 4, 2020
Accepted: September 16, 2020
Article in press: September 16, 2020
Published online: November 26, 2020
Processing time: 212 Days and 21.5 Hours
Peer-review started: April 26, 2020
First decision: August 23, 2020
Revised: September 4, 2020
Accepted: September 16, 2020
Article in press: September 16, 2020
Published online: November 26, 2020
Processing time: 212 Days and 21.5 Hours
Core Tip
Core Tip: We examined the serum lactate dehydrogenase (LDH) and clinical characteristics in critical coronavirus disease 2019 (COVID-19) patients and their predictive value for prognosis. We retrospectively evaluated 47 critical COVID-19 patients and divided them into non-survivors and survivors. Clinical data including symptoms, detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), chest computed tomography images, changes in serum LDH in different clinical phases, and prognosis were collected. In this study, high LDH was positively correlated with worsening overall survival. High LDH and dyspnea symptoms were positive predictors of adverse outcome in critical COVID-19 patients. The rapid progressive fibrosis stage may be more perilous than the alveolitis stage, even if SARS-CoV-2 is undetectable.