Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2020; 8(22): 5529-5534
Published online Nov 26, 2020. doi: 10.12998/wjcc.v8.i22.5529
Osteoprotegerin, interleukin and hepatocyte growth factor for prediction of diabetes and hypertension in the third trimester of pregnancy
Su-Jing Huang, Hong-Wei Wang, Hai-Fang Wu, Qiu-Yuan Wei, Shu Luo, Lin Xu, Hong-Qiong Guan
Su-Jing Huang, Hong-Wei Wang, Hai-Fang Wu, Qiu-Yuan Wei, Shu Luo, Lin Xu, Hong-Qiong Guan, Department of Obstetrics, The Second Affiliated Hospital of Hainan Medical College, Haikou 570311, Hainan Province, China
Author contributions: Huang SJ and Wang HW contributed equally to this manuscript; Huang SJ, Wang HW, Wu HF, Wei QY, Luo S, Xu L and Guan HQ collected data and wrote the manuscript; Guan HQ reviewed the manuscript.
Supported by Hainan Province Major Program of Science and Technology Projects 2017, No. ZDKJ2017007.
Institutional review board statement: The study was reviewed and approved by Institutional Review Board of The Second Affiliated Hospital of Hainan Medical College.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare they have no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Qiong Guan, MD, Chief Physician, Department of Obstetrics, The Second Affiliated Hospital of Hainan Medical College, No. 48 Baishuitang Road, Haikou 570311, Hainan Province, China. guanhq1962@163.com
Received: September 1, 2020
Peer-review started: September 1, 2020
First decision: September 13, 2020
Revised: September 24, 2020
Accepted: October 1, 2020
Article in press: October 1, 2020
Published online: November 26, 2020
Core Tip

Core Tip: Gestational diabetes mellitus (GDM) and gestational hypertension (GH) are associated with serious and long-term feto-maternal and neonatal outcomes compared to normal pregnancies. Although oral glucose tolerance tests and blood pressure tests were accepted criteria for screenings of GDM and GH, these criteria might not anticipate or detect all GDM or GH cases. Biomarkers may serve as adjunct predictors for GDM and GH. The present study explored osteoprotegerin, interleukin and hepatocyte growth factor for prediction of GDM and GH.