Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2020; 8(15): 3267-3279
Published online Aug 6, 2020. doi: 10.12998/wjcc.v8.i15.3267
Multi-organ IgG4-related disease continues to mislead clinicians: A case report and literature review
Sandra Strainiene, Lukas Sarlauskas, Ilona Savlan, Valentina Liakina, Ieva Stundiene, Jonas Valantinas
Sandra Strainiene, Ilona Savlan, Valentina Liakina, Ieva Stundiene, Jonas Valantinas, Clinic of Gastroenterology, Nephrourology and Surgery, Centre of Hepatology, Gastroenterology and Dietetics, Institute of Clinical Medicine, Vilnius University, Vilnius 01513, Lithuania
Lukas Sarlauskas, Clinic of Internal Diseases, Family Medicine and Oncology, Centre of Internal Diseases, Institute of Clinical Medicine, Vilnius University, Vilnius 01513, Lithuania
Valentina Liakina, Department of Chemistry and Bioengineering, Faculty of Fundamental Science, Vilnius Gediminas Technical University, Vilnius 10223, Lithuania
Author contributions: Savlan I was the gastroenterologist who followed-up the patient; Strainiene S, Sarlauskas L and Savlan I performed patient's data extraction; Strainiene S and Sarlauskas L wrote the original manuscript and reviewed the literature; Savlan I, Liakina V and Stundiene I reviewed and edited the manuscript; Savlan I, Liakina V, Stundiene I and Valantinas J were responsible for the revision of the manuscript for the important intellectual content; all the authors issued the final approval for the version to be submitted and agreed to be accountable for all aspects of the work.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sandra Strainiene, MD, Doctor, Clinic of Gastroenterology, Nephrourology and Surgery, Centre of Hepatology, Gastroenterology and Dietetics, Institute of Clinical Medicine, Vilnius University, 3 Universiteto Street, Vilnius 01513, Lithuania. sandra.strainiene@santa.lt
Received: April 15, 2020
Peer-review started: April 15, 2020
First decision: April 26, 2020
Revised: May 7, 2020
Accepted: July 15, 2020
Article in press: July 15, 2020
Published online: August 6, 2020
Processing time: 113 Days and 3.5 Hours
Core Tip

Core tip: Immunoglobulin G4-related disease (IgG4-RD) is a rare multisystemic immune-mediated disease that affects almost every organ and mimics various malignant, infectious or other inflammatory conditions. Therefore, the correct diagnosis and proper treatment are often delayed. We present the first clinical case of multi-organ IgG4-RD from Lithuania and the Baltic Sea region that reveals the importance of a comprehensive approach to the patient in order to achieve effective recognition of the rare immune system malfunction conditions such as IgG4-RD.