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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2020; 8(11): 2280-2293
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2280
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2280
Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies
Hao-Yu Yang, Yu-Zhou Liu, Department of Orthopedics, Wuxi 9th People’s Hospital affiliated to Soochow University, Wuxi 214000, Jiangsu Province, China
Xin-Die Zhou, Yong Huang, Nan-Wei Xu, Department of Orthopedics, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China
Author contributions: Yang HY and Liu YZ contributed equally to this work; Yang YH, Huang Y, and Xu NW designed the research; Yang YH, Liu YZ and Zhou XD performed the research; Yang HY and Liu YZ contributed new reagents/analytic tools; Zhou XD and Xu NW analyzed the data; and Yang YH, Liu YZ and Huang Y wrote the paper.
Supported by National Natural Science Foundation of China , No. 81702179 ; Major Scientific and Technological Project of Changzhou Municipal Commission of Health and Family Planning , No. ZD201809 .
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The guidelines of the PRISMA 2009 Statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yong Huang, MD, Doctor, Full Professor, Department of Orthopedics, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, No. 29 Xinglong Road, Tianning District, Changzhou 213003, Jiangsu Province, China. huangyong@njmu.edu.cn
Received: December 11, 2019
Peer-review started: December 11, 2019
First decision: January 7, 2020
Revised: March 6, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: June 6, 2020
Peer-review started: December 11, 2019
First decision: January 7, 2020
Revised: March 6, 2020
Accepted: April 24, 2020
Article in press: April 24, 2020
Published online: June 6, 2020
Core Tip
Core tip: Osteoarthritis (OA) is the combined result of complex pathogenic factors, including mechanical, biochemical, environmental, endocrine, metabolic, and genetic factors, which account for nearly 50% of the risk of OA development. Although the pathogenesis and etiology of OA are not known, it is likely that interleukin-17 (IL-17) might play an important role in OA development. Existing studies on the association between polymorphisms of the IL-17 gene and the risk of OA in different populations have yielded conflicting findings. We meta-analyzed relevant articles to pool available data and investigated whether IL-17 gene polymorphisms were associated with OA susceptibility.