Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2020; 8(11): 2127-2136
Published online Jun 6, 2020. doi: 10.12998/wjcc.v8.i11.2127
Clinical prediction of complicated appendicitis: A case-control study utilizing logistic regression
Yosuke Sasaki, Fumiya Komatsu, Naoyasu Kashima, Takeshi Suzuki, Ikutaka Takemoto, Sho Kijima, Tadashi Maeda, Taito Miyazaki, Yoshiko Honda, Hiroaki Zai, Nagato Shimada, Kimihiko Funahashi, Yoshihisa Urita
Yosuke Sasaki, Fumiya Komatsu, Naoyasu Kashima, Takeshi Suzuki, Ikutaka Takemoto, Sho Kijima, Tadashi Maeda, Taito Miyazaki, Yoshiko Honda, Nagato Shimada, Yoshihisa Urita, Department of General Medicine and Emergency Care, Toho University School of Medicine, Ota-ku, Tokyo 143-8541, Japan
Kimihiko Funahashi, Department of General and Gastroenterological Surgery, Toho University Omori Medical Center, Otaku, Tokyo 143-8541, Japan
Author contributions: Sasaki Y designed the research, collected data, and wrote the manuscript; Komatsu F, Kashima N, and Suzuki T collected data with Sasaki Y; Takemoto I and Kijima S assisted in data collection; Maeda T and Miyazaki T advised on the discussion as experts of infectious diseases; Honda Y, Shimada N, and Funahashi K advised on the discussion as surgeons; and Urita Y supervised the research and advised on statistical analyses.
Institutional review board statement: The ethics committee of Toho University Medical Center Omori Hospital approved the study’s protocol (M19023).
Informed consent statement: The center’s ethics committee approved the waiver of individual informed consent subject to public announcement of the research because of the retrospective and noninvasive study design.
Conflict-of-interest statement: None.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yosuke Sasaki, MD, PhD, Assistant Professor, Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo 143-8541, Japan. yousuke.sasaki@med.toho-u.ac.jp
Received: February 13, 2020
Peer-review started: February 13, 2020
First decision: April 1, 2020
Revised: April 8, 2020
Accepted: May 13, 2020
Article in press: May 13, 2020
Published online: June 6, 2020
Processing time: 115 Days and 17 Hours
Core Tip

Core tip: Given few multivariate analyses on C-reactive protein (CRP) as a predictor of complicated appendicitis (CA), we performed a logistic regression analysis of 198 patients with simple appendicitis and 38 patients with CA. The regression model including non-laboratory factors of CA showed that age ≥ 65 years old, longer onset-to-visit interval, and anorexia had significantly high odds ratios. The logistic regression that additionally included laboratory data showed that only elevated CRP levels had significantly high odds ratios, which suggested that high CRP level can be a dose-dependent predictor of CA.