Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2020; 8(10): 1908-1915
Published online May 26, 2020. doi: 10.12998/wjcc.v8.i10.1908
Risk factors, incidence, and morbidity associated with antibiotic-associated diarrhea in intensive care unit patients receiving antibiotic monotherapy
Hong Zhou, Qiang Xu, Yu Liu, Li-Tao Guo
Hong Zhou, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Qiang Xu, Yu Liu, Li-Tao Guo, Department of Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Guo LT designed the study and analyzed the data; all authors contributed to data collection; Zhou H and Xu Q wrote the manuscript; Zhou H and Guo LT revised the manuscript; Liu Y and Guo LT helped select the patients for the study; Zhou H and Xu Q contributed equally to this paper.
Supported by the Clinical Research Award of the First Affiliated Hospital of Xi’ an Jiaotong University, China, No. XJTU1AF-CRF-2018-011; and the Institutional Foundation of the First Affiliated Hospital of Xi’ an Jiaotong University, No. 2018MS-11.
Institutional review board statement: This study was reviewed and approved by the First Affiliated hospital of Xi'an Jiaotong University Ethics committee, No. XJTU1AF2018LSL-011.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no competing financial interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Li-Tao Guo, MD, PhD, Director, Department of Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Xi’an 710061, Shaanxi Province, China. glt2002@xjtu.edu.cn
Received: February 19, 2020
Peer-review started: February 19, 2020
First decision: March 18, 2020
Revised: April 9, 2020
Accepted: April 29, 2020
Article in press: April 29, 2020
Published online: May 26, 2020
Processing time: 96 Days and 5.1 Hours
Core Tip

Core tip: In this retrospective study, clinical data were retrospectively analyzed in patients hospitalized at the First Affiliated Hospital of Xi’an Jiaotong University. Factors related to antibiotic-associated diarrhea (AAD) were analyzed in critically ill patients receiving antibiotic monotherapy. The total incidence of AAD was 21.53%. Patients with AAD had a longer intensive care unit (ICU) stay time than patients without AAD (15.89 ± 10.69 vs 8.49 ± 6.31, P < 0.001). Older age, longer ICU stay time, duration of use of proton pump inhibitors and duration of antibiotic increase the incidence of AAD in ICU patients receiving antibiotic monotherapy.