Published online May 26, 2020. doi: 10.12998/wjcc.v8.i10.1908
Peer-review started: February 19, 2020
First decision: March 18, 2020
Revised: April 9, 2020
Accepted: April 29, 2020
Article in press: April 29, 2020
Published online: May 26, 2020
Processing time: 96 Days and 5.1 Hours
Antibiotic-associated diarrhea (AAD) is diarrhea associated with antibiotic administration. Its incidence has gradually increased and has been reported to be as high as 35% in some studies. AAD has become an important nosocomial disease, especially in critically ill patients. Therefore, we aimed to investigate the factors related to AAD in intensive care unit (ICU) patients receiving antibiotic monotherapy and to provide evidence for clinical anti-infective treatment in critically ill patients.
Currently, research studies on AAD found in the literature are primarily focused on ordinary patients, but a study on AAD in critically ill individuals showed that the incidence of AAD can be as high as 21.6% in cases where antibiotic monotherapy is applied. However, the factors that are associated with AAD in ICU patients with antibiotic monotherapy have not been further explored.
This study aimed to identify factors related to AAD in patients in the ICU receiving antibiotic monotherapy to reduce the incidence of AAD and improve rational use of antibiotics in these patients.
A total of 209 patients were enrolled from the ICU of the First Affiliated Hospital of Xi'an Jiaotong University and received antibiotic monotherapy from January 2014 to February 2017. There were 45 cases in the AAD group and 164 cases in the no-AAD group.
The overall incidence of AAD was 21.53%. Age, proton pump inhibitor usage time, duration of antibiotic, and ICU stay time were associated with AAD. Mean ICU stay time was lower in the no-AAD group (8.49 ± 6.31 vs 15.89 ± 10.69, P < 0.001). However, there was no significant difference in ICU-related mortality rates between the two groups.
Older age, longer ICU stay time, proton pump inhibitor usage time, and duration of antibiotic increase the incidence of AAD in ICU patients receiving antibiotic monotherapy.
We aimed to investigate the factors related to AAD in ICU patients receiving antibiotic monotherapy and provide evidence for clinical anti-infective treatment in critically ill patients.