Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2019; 7(11): 1330-1336
Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1330
Paraneoplastic leukemoid reaction in a patient with sarcomatoid hepatocellular carcinoma: A case report
Bo Hu, Xin-Ting Sang, Xiao-Bo Yang
Bo Hu, Xin-Ting Sang, Xiao-Bo Yang, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: Hu B collected the patient’s clinical data and wrote the paper; Sang XT and Yang XB analyzed the data and designed the report.
Informed consent statement: Consent was obtained from the patient at the time of investigations, but not at the time of writing this case report.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xin-Ting Sang, MD, Director, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. sangxt@pumch.cn
Telephone: +86-010-69152836 Fax: +86-010-69156043
Received: January 21, 2019
Peer-review started: January 22, 2019
First decision: March 9, 2019
Revised: April 2, 2019
Accepted: April 18, 2019
Article in press: April 19, 2019
Published online: June 6, 2019
Processing time: 137 Days and 4 Hours
Core Tip

Core tip: Sarcomatoid hepatocellular carcinoma (SHC) is a rare histological subtype of hepatocellular carcinoma (HCC), with largely incompletely described clinical manifestations and outcomes. SHC combined with paraneoplastic leukemoid reaction (PLR), which is defined as reactive leukocytosis exceeding 50000/μL, is associated with a poor prognosis and is rarely seen in the clinic. A surgery or surgery-centered multidisciplinary team may benefit patients in this situation.