Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2018; 6(10): 355-364
Published online Sep 26, 2018. doi: 10.12998/wjcc.v6.i10.355
PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease
Ji-Jun Luo, Hai-Xia Cao, Rui-Xu Yang, Rui-Nan Zhang, Qin Pan
Ji-Jun Luo, Hai-Xia Cao, Rui-Xu Yang, Rui-Nan Zhang, Qin Pan, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Author contributions: Pan Q conceived and designed the experiments; Luo JJ, Yang RX and Zhang RN performed the experiments; Luo JJ and Cao HX analyzed the data; Pan Q wrote the paper; Luo JJ and Cao HX contributed equally to this work.
Supported by National Key Research and Development Plan “Precision Medicine Research” , No. 2017YFC0908903; National Natural Science Foundation of China, No. 81070346, No. 81270492, No. 81470859, No. 81270491 and No. 81470840; State Key Development Program for Basic Research of China, No. 2012CB517501; 100 Talents Program, No. XBR2011007h; and Program of the Committee of Science and Technology, No. 09140903500.
Institutional review board statement: The study was reviewed and approved by the Xinhua Hospital Ethics Committee Affiliated to Shanghai Jiaotong University School of Medicine.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Kongjiang Road NO. 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn
Telephone: +86-21-63846590 Fax: +86-21-25077340
Received: June 19, 2018
Peer-review started: June 19, 2018
First decision: July 11, 2018
Revised: July 16, 2018
Accepted: August 3, 2018
Article in press: August 4, 2018
Published online: September 26, 2018
Processing time: 100 Days and 4.3 Hours
Core Tip

Core tip:PNPLA3 single nucleotide polymorphisms reflect an important genetic basis of serum lipidomics, especially phospholipid metabolites, in nonalcoholic fatty liver disease (NAFLD) patients. PNPLA3 rs139051 (A/A genotype) exerts an up-regulatory effect on phospholipids of lysophosphatidylcholines (LPCs) and lysophosphatidylcholine plasmalogens (LPCOs). Moreover, both the A/A genotype at PNPLA3 rs139051 and high-level LPCs/LPCOs share an association with the low-grade lobular inflammation of NAFLD. Therefore, PNPLA3 rs139051 may underlie the inflammatory progress of NAFLD with its modulation of phospholipid metabolite profiles.