Editorial
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2025; 13(13): 101438
Published online May 6, 2025. doi: 10.12998/wjcc.v13.i13.101438
Genetic insights in infectious diseases: Insights from a case report and implications for personalized medicine
Suryasnata Bhowmik, Adrija Hajra, Dhrubajyoti Bandyopadhyay
Suryasnata Bhowmik, Department of Medicine, Nilratan Sircar Medical College, Kolkata 700156, West Bengal, India
Adrija Hajra, Department of Medicine, Brigham and Women’s Hospital/Mass General Brigham, Boston, MA 02115, United States
Dhrubajyoti Bandyopadhyay, Department of Cardiovacular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States
Co-first authors: Suryasnata Bhowmik and Adrija Hajra.
Author contributions: Bhowmik S designed the overall concept and outline of the manuscript; Hajra A contributed to the discussion and design of the manuscript; Bhowmik S and Hajra A contributed equally to this article, they are the co-first authors of this manuscript; Bhowmik S, Hajra A, and Bandyopadhyay D contributed to the writing, and editing the manuscript, illustrations, and review of literature; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dhrubajyoti Bandyopadhyay, MD, Department of Cardiovacular Imaging, Massachusetts General Hospital, Harvard Medical School, No. 55 Fruit Sreet, Boston, MA 02114, United States. drdhrubajyoti87@gmail.com
Received: September 14, 2024
Revised: December 10, 2024
Accepted: December 23, 2024
Published online: May 6, 2025
Processing time: 119 Days and 9.1 Hours
Core Tip

Core Tip: Genetics significantly impacts infectious disease outcomes, from susceptibility to treatment responses. Key genetic variations, such as those in heme-oxygenase-1 and vaccine-related markers, influence how individuals respond to infections and vaccinations. The study of drug-resistant tuberculosis highlights the complex role of genomic variants, requiring advanced diagnostic tools. Genome-wide association studies and host polymorphisms, like solute carrier family 11 member 1 and vitamin D receptor, provide insights into disease mechanisms and resistance.