Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2024; 12(8): 1416-1421
Published online Mar 16, 2024. doi: 10.12998/wjcc.v12.i8.1416
Safety and effectiveness of butorphanol in epidural labor analgesia: A protocol for a systematic review and meta-analysis
Guan-Cheng Tang, Man He, Zhen-Zhao Huang, Yan Cheng
Guan-Cheng Tang, Department of Anesthesiology, Yongkang Hospital of Traditional Chinese Medicine, Jinhua 321301, Zhejiang Province, China
Man He, Department of Gynecology and Obstetrics, Yongkang Hospital of Traditional Chinese Medicine, Jinhua 321301, Zhejiang Province, China
Zhen-Zhao Huang, Department of Anesthesiology, Hangzhou United Liger Sixth Medical Beauty Hospital, Hangzhou 311215, Zhejiang Province, China
Yan Cheng, Department of Ultrasound, Hangzhou Women’s Hospital, Hangzhou 310008, Zhejiang Province, China
Co-first authors: Guan-Cheng Tang and Man He.
Author contributions: Tang GC and He M contributed equally to this work, Tang GC contributed substantially to the design and conception of the study and drafted the manuscript; Huang ZZ and He M developed the search criteria with input from Tang GC and Cheng Y; He M contributed to the design of the statistical methods; He M and Tang GC coordinated the whole process; Cheng Y supervised the protocol development process; All the authors revised the manuscript critically for important intellectual content, approved the final submission, and agreed to be held accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Cheng, Doctor, Attending Doctor, Department of Ultrasound, Hangzhou Women’s Hospital, No. 369 Kunpeng Road, Shangcheng District, Hangzhou 310008, Zhejiang Province, China. chengy8920@163.com
Received: November 12, 2023
Peer-review started: November 12, 2023
First decision: December 28, 2023
Revised: January 9, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 16, 2024
Processing time: 120 Days and 18.5 Hours
Core Tip

Core Tip: Because κ-receptors appear to be involved in visceral pain modulation, butorphanol, which has a strong visceral component, has been recommended as an effective treatment for labor-related pain. Nevertheless, no study has comprehensively examined the effectiveness and safety of using butorphanol as an epidural analgesic during labor. The safety and effectiveness of butorphanol for epidural analgesia during labor will be thoroughly and systematically investigated in this study. Future research and clinical practice will benefit from the conclusions of the present study.