Tang GC, He M, Huang ZZ, Cheng Y. Safety and effectiveness of butorphanol in epidural labor analgesia: A protocol for a systematic review and meta-analysis. World J Clin Cases 2024; 12(8): 1416-1421 [PMID: 38576817 DOI: 10.12998/wjcc.v12.i8.1416]
Corresponding Author of This Article
Yan Cheng, Doctor, Attending Doctor, Department of Ultrasound, Hangzhou Women’s Hospital, No. 369 Kunpeng Road, Shangcheng District, Hangzhou 310008, Zhejiang Province, China. chengy8920@163.com
Research Domain of This Article
Anesthesiology
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 16, 2024; 12(8): 1416-1421 Published online Mar 16, 2024. doi: 10.12998/wjcc.v12.i8.1416
Safety and effectiveness of butorphanol in epidural labor analgesia: A protocol for a systematic review and meta-analysis
Guan-Cheng Tang, Man He, Zhen-Zhao Huang, Yan Cheng
Guan-Cheng Tang, Department of Anesthesiology, Yongkang Hospital of Traditional Chinese Medicine, Jinhua 321301, Zhejiang Province, China
Man He, Department of Gynecology and Obstetrics, Yongkang Hospital of Traditional Chinese Medicine, Jinhua 321301, Zhejiang Province, China
Zhen-Zhao Huang, Department of Anesthesiology, Hangzhou United Liger Sixth Medical Beauty Hospital, Hangzhou 311215, Zhejiang Province, China
Yan Cheng, Department of Ultrasound, Hangzhou Women’s Hospital, Hangzhou 310008, Zhejiang Province, China
Co-first authors: Guan-Cheng Tang and Man He.
Author contributions: Tang GC and He M contributed equally to this work, Tang GC contributed substantially to the design and conception of the study and drafted the manuscript; Huang ZZ and He M developed the search criteria with input from Tang GC and Cheng Y; He M contributed to the design of the statistical methods; He M and Tang GC coordinated the whole process; Cheng Y supervised the protocol development process; All the authors revised the manuscript critically for important intellectual content, approved the final submission, and agreed to be held accountable for all aspects of the work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Cheng, Doctor, Attending Doctor, Department of Ultrasound, Hangzhou Women’s Hospital, No. 369 Kunpeng Road, Shangcheng District, Hangzhou 310008, Zhejiang Province, China. chengy8920@163.com
Received: November 12, 2023 Peer-review started: November 12, 2023 First decision: December 28, 2023 Revised: January 9, 2024 Accepted: February 18, 2024 Article in press: February 18, 2024 Published online: March 16, 2024 Processing time: 120 Days and 18.5 Hours
Abstract
BACKGROUND
Epidural analgesia is the most effective analgesic method during labor. Butorphanol administered epidurally has been shown to be a successful analgesic method during labor. However, no comprehensive study has examined the safety and efficacy of using butorphanol as an epidural analgesic during labor.
AIM
To assess butorphanol's safety and efficacy for epidural labor analgesia.
METHODS
The PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure, and Google Scholar databases will be searched from inception. Other types of literature, such as conference abstracts and references to pertinent reviews, will also be reviewed. We will include randomized controlled trials comparing butorphanol with other opioids combined with local anesthetics for epidural analgesia during labor. There will be no language restrictions. The primary outcomes will include the visual analog scale score for the first stage of labor, fetal effects, and Apgar score. Two independent reviewers will evaluate the full texts, extract data, and assess the risk of bias. Publication bias will be evaluated using Egger's or Begg's tests as well as visual analysis of a funnel plot, and heterogeneity will be evaluated using the Cochran Q test, P values, and I2 values. Meta-analysis, subgroup analysis, and sensitivity analysis will be performed using RevMan software version 5.4. This protocol was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Protocols statement, and the PRISMA statement will be used for the systematic review.
RESULTS
This study provides reliable information regarding the safety and efficacy of using butorphanol as an epidural analgesic during labor.
CONCLUSION
To support clinical practice and development, this study provides evidence-based findings regarding the safety and efficacy of using butorphanol as an epidural analgesic during labor.
Core Tip: Because κ-receptors appear to be involved in visceral pain modulation, butorphanol, which has a strong visceral component, has been recommended as an effective treatment for labor-related pain. Nevertheless, no study has comprehensively examined the effectiveness and safety of using butorphanol as an epidural analgesic during labor. The safety and effectiveness of butorphanol for epidural analgesia during labor will be thoroughly and systematically investigated in this study. Future research and clinical practice will benefit from the conclusions of the present study.
