Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2024; 12(5): 931-941
Published online Feb 16, 2024. doi: 10.12998/wjcc.v12.i5.931
Value of glucose transport protein 1 expression in detecting lymph node metastasis in patients with colorectal cancer
Hongsik Kim, Song-Yi Choi, Tae-Young Heo, Kyeong-Rok Kim, Jisun Lee, Min Young Yoo, Taek-Gu Lee, Joung-Ho Han
Hongsik Kim, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju 28644, South Korea
Song-Yi Choi, Department of Pathology, Chungnam National University College of Medicine, Daejeon 35015, South Korea
Tae-Young Heo, Kyeong-Rok Kim, Information and Statistics, Chungbuk National University, Cheongju 28644, South Korea
Jisun Lee, Department of Radiology, College of Medicine, Chungbuk National University, Chungbuk National University Hospital, Cheongju-si 28644, South Korea
Min Young Yoo, Department of Nuclear Medicine, School of Medicine, Inha University, Incheon 22332, South Korea
Taek-Gu Lee, Department of Surgery, Chungbuk National University, College of Medicine, Cheongju-si 28644, South Korea
Joung-Ho Han, Department of Internal Medicen, Chungbuk National University, College of medicine, Cheongju-si 28644, South Korea
Co-first authors: Hongsik Kim and Song-Yi Choi.
Author contributions: contributed to Kim H, Choi SY, Heo TY, Kim KR, Lee J, Yoo MY, Lee TG, and Han JH conceptualization, data curation, writing—review & editing; Heo TY and Kim KR contributed to formal analysis, software; Han JH contributed to funding acquisition, project administration, supervision; Kim H, Choi SY, Heo TY, Kim KR, and Han JH contributed to investigation, methodology, validation; Kim H and Choi SY contributed to visualization; Kim H, Choi SY, and Han JH contributed to writing - original draft.
Institutional review board statement: The Institutional Review Board (IRB No. 2013-03-003) of Chungbuk National University Hospital approved this study.
Informed consent statement: The requirement for written informed consent was waived due to retrospective design of the study.
Conflict-of-interest statement: The authors have no conflict of interest to declare regarding the publication of this work.
Data sharing statement: IRB of CBNUH did not permit sharing the raw data of patients without consent.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joung-Ho Han, MD, PhD, Professor, Department of Internal Medicen, Chungbuk National University, College of medicine, No. 1 Chungdae-ro, Seowon-gu, Cheongju-si 28644, South Korea. joungho@chungbuk.ac.kr
Received: November 9, 2023
Peer-review started: November 9, 2023
First decision: December 21, 2023
Revised: January 4, 2024
Accepted: January 22, 2024
Article in press: January 22, 2024
Published online: February 16, 2024
Processing time: 82 Days and 22.4 Hours
Core Tip

Core Tip: Glucose transport protein 1 (GLUT-1) expression is a significant predictor of lymph node metastasis in patients with colorectal cancer. Positron emission tomography/computed tomography showed a higher sensitivity for detecting lymph node metastasis for GLUT-1-positive tumors, suggesting that GLUT-1 expression can be used to improve the accuracy of preoperative staging and guide treatment planning in patients with colorectal cancer.