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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 26, 2024; 12(3): 525-537
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.525
Published online Jan 26, 2024. doi: 10.12998/wjcc.v12.i3.525
Emerging roles of microRNAs as diagnostics and potential therapeutic interest in type 2 diabetes mellitus
Dharmsheel Shrivastav, Desh Deepak Singh, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India
Author contributions: Shrivastav D and Singh DD design and written the manuscript and all data were generated in-house and that no paper mill was used.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Desh Deepak Singh, PhD, Associate Professor, Amity Institute of Biotechnology, Amity University Rajasthan, SP-1, Kant Kalwar, RIICO Industrial Area, NH-11C, Jaipur 303002, Rajasthan, India. ddsbms@gmail.com
Received: November 7, 2023
Peer-review started: November 7, 2023
First decision: December 15, 2023
Revised: December 18, 2023
Accepted: January 3, 2024
Article in press: January 3, 2024
Published online: January 26, 2024
Peer-review started: November 7, 2023
First decision: December 15, 2023
Revised: December 18, 2023
Accepted: January 3, 2024
Article in press: January 3, 2024
Published online: January 26, 2024
Core Tip
Core Tip: Type 2 diabetes mellitus (T2DM) is a worldwide problem characterized by uncontrolled hyperglycemia. In T2DM, elevated glucose bound proteins and leading to formation advanced glycation end products. miRNAs play a major role in gene regulation of different proteins which are involved in various metabolic pathways including nuclear factor kappa beta, protein kinase C, and phosphoinositide-3-kinase–protein kinase B/Akt which are responsible for blood glucose and insulin secretion and T2DM. The target of these miRNA changes the regulation of metabolic pathways which can reduce oxidative stress and inflammation. So, the modulate the regulation of these miRNA could be possible approach of the treatment of T2DM.