Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior: Two case reports

doi:10.12998/wjcc.v12.i22.5124

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Aug 6, 2024 (publication date) through Jul 2, 2024

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Clin Cases. Aug 6, 2024; 12(22): 5124-5130
Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5124

Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior: Two case reports

Hui-Hui Cao, Hong Li, Xiao-Hong Guo, Zhi-Xing Cao, Bo-Hui Zhang

Hui-Hui Cao, Hong Li, Xiao-Hong Guo, Zhi-Xing Cao, Bo-Hui Zhang, Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai 519000, Guangdong Province, China

Author contributions: Cao ZX and Guo XH made the final pathological diagnosis; Zhang BH performed immunohistochemical studies and analyzed the molecular data; Cao HH, Li H summarized the pathological and clinical data, organized the study and wrote the manuscript. All authors have read and approved the final manuscript.

Informed consent statement: Informed consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Bo-Hui Zhang, BM BCh, Technician, Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), No. 79 Kangning Road, Zhuhai 519000, Guangdong Province, China. 412338793@qq.com

Received: February 3, 2024
Revised: May 29, 2024
Accepted: June 17, 2024
Published online: August 6, 2024
Processing time: 149 Days and 21.7 Hours

Core Tip

Core Tip: Most patients with eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC) have an indolent nature, but 8 cases have exhibited metastatic potential. In this study, we made a clear diagnosis in 2 cases of ESC RCC, including a case with multifocal metastases, by pathological microscopy, immunohistochemistry, next-generation sequencing, or whole exome sequencing analysis, which played a crucial role in clinical treatment. Usually, ESC RCC has a solid and cystic growth pattern, a voluminous eosinophilic cytoplasm with coarse basophilic stippling, is CK20 positive and has TSC1/2 mutations.