Cao HH, Li H, Guo XH, Cao ZX, Zhang BH. Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior: Two case reports. World J Clin Cases 2024; 12(22): 5124-5130 [PMID: 39109003 DOI: 10.12998/wjcc.v12.i22.5124]
Corresponding Author of This Article
Bo-Hui Zhang, BM BCh, Technician, Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), No. 79 Kangning Road, Zhuhai 519000, Guangdong Province, China. 412338793@qq.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2024; 12(22): 5124-5130 Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5124
Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior: Two case reports
Hui-Hui Cao, Hong Li, Xiao-Hong Guo, Zhi-Xing Cao, Bo-Hui Zhang
Hui-Hui Cao, Hong Li, Xiao-Hong Guo, Zhi-Xing Cao, Bo-Hui Zhang, Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai 519000, Guangdong Province, China
Author contributions: Cao ZX and Guo XH made the final pathological diagnosis; Zhang BH performed immunohistochemical studies and analyzed the molecular data; Cao HH, Li H summarized the pathological and clinical data, organized the study and wrote the manuscript. All authors have read and approved the final manuscript.
Informed consent statement: Informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bo-Hui Zhang, BM BCh, Technician, Department of Pathology, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), No. 79 Kangning Road, Zhuhai 519000, Guangdong Province, China. 412338793@qq.com
Received: February 3, 2024 Revised: May 29, 2024 Accepted: June 17, 2024 Published online: August 6, 2024 Processing time: 149 Days and 21.7 Hours
Abstract
BACKGROUND
Eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC), a unique and emerging subtype of RCC, has an indolent nature; in some rare instances, it may exhibit metastatic potential. Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.
CASE SUMMARY
Herein, we report two patients with ESC RCC. Patient 1 was a young woman with classical pathological characteristics. Patient 2 was a 52-year-old man with multifocal metastases, involving the pulmonary hilar and mediastinal lymph nodes, liver, brain, mesosternum, vertebra, rib, femur, and symphysis pubis. Awareness of ESC RCC, along with its characteristic architecture and immunophenotype, would contribute to making a definitive diagnosis, even on core biopsy samples.
CONCLUSION
The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.
Core Tip: Most patients with eosinophilic solid and cystic (ESC) renal cell carcinoma (RCC) have an indolent nature, but 8 cases have exhibited metastatic potential. In this study, we made a clear diagnosis in 2 cases of ESC RCC, including a case with multifocal metastases, by pathological microscopy, immunohistochemistry, next-generation sequencing, or whole exome sequencing analysis, which played a crucial role in clinical treatment. Usually, ESC RCC has a solid and cystic growth pattern, a voluminous eosinophilic cytoplasm with coarse basophilic stippling, is CK20 positive and has TSC1/2 mutations.
