Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 16, 2023; 11(5): 1188-1197
Published online Feb 16, 2023. doi: 10.12998/wjcc.v11.i5.1188
Early postsurgical lethal outcome due to splenic littoral cell angioma: A case report
Fan Jia, Han Lin, Yi-Long Li, Jin-Ling Zhang, Liang Tang, Peng-Tian Lu, Yu-Qing Wang, Yi-Feng Cui, Xiu-Hua Yang, Zhao-Yang Lu
Fan Jia, Xiu-Hua Yang, Department of Abdominal Ultrasound, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Han Lin, Yi-Feng Cui, Zhao-Yang Lu, Department of Hepatic Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Yi-Long Li, Department of Pancreatic and Biliary Surgery, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Jin-Ling Zhang, Liang Tang, Department of Radiology and Nuclear Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Peng-Tian Lu, Department of Pathology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Yu-Qing Wang, Department of Hematopathology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China
Author contributions: Jia F and Lin H two authors contributed equally to this work, contributed to data extraction, analysis and interpretation, reviewed literature, manuscript writing and editing; Li YL, Zhang JL, Tang L, Lu PT, Wang YQ, and Cui YF provided technical support and professional advice and contributed to manuscript writing and editing; Yang XH and Lu ZY supervised the project until its completion and contributed equally to this work; all authors contributed to the interpretation of the results; all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81972230; Hubei Technological Innovation Special Fund (CN), No. CXPJJH11800004-004, No. CXPJJH122002-063, and No. CXPJJH122002-092; University Nursing Program for Young Scholar with Creative Talents in Heilongjiang Province, No. UNPYSCT-2017064; Postdoctoral Foundation of Hei Long Jiang Province, No. LBH-Z20196 and No. LBH-Z20178; China Postdoctoral Science Foundation, No. 2021MD703835; Wu Jie-Ping Medical Foundation, No. 320.6750.2021-23-22; Open Fund of Key Laboratory of Hepatosplenic Surgery, Ministery of Education, Harbin, China, No. GPKF202204; Excellent Youth Science Fund of the First Hopital of Harbin Medical University, No. 2021Y01; and Scientifc Foundation of the First Afliated Hospital of Harbin Medical University, No. 2021B03.
Informed consent statement: Informed written consent was obtained from the patient’s family member for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Hua Yang, MD, PhD, Chief Physician, Professor, Department of Abdominal Ultrasound, First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Road, Nangang District, Harbin 150001, Heilongjiang Province, China. yangxiuhua@hrbmu.edu.cn
Received: November 14, 2022
Peer-review started: November 14, 2022
First decision: November 30, 2022
Revised: December 9, 2022
Accepted: January 16, 2023
Article in press: January 16, 2023
Published online: February 16, 2023
Processing time: 91 Days and 22.2 Hours
Core Tip

Core Tip: Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen. No standard diagnostic and therapeutic recommendations are available. We report a patient with LCA and without comorbidities who died of multiple organ dysfunction syndrome 4 mo after surgery, which is extremely rare. Systematic analysis of relevant cases in the PubMed, Embase, Web of Science and the Cochrane Library databases revealed that LCA has a close relationship with malignancy and immunodysregulation. The possibility of LCA should not be overlooked when a patient presents with splenic tumors and malignancy or immune-related disease. Considering its potential malignant behavior, total splenectomy (including accessory spleen) and regular follow-up after surgery are recommended.