Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2023; 11(28): 6670-6679
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6670
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6670
Neurotransmitters regulate β cells insulin secretion: A neglected factor
Chu-Chu Kong, Ji-Dong Cheng, Wei Wang, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361100, Fujian Province, China
Author contributions: Kong CC wrote and revised the manuscript; Cheng JD searched references; Wang W proposed ideas and gave final approval for the submission.
Supported by National Natural Science Foundation of China , No. 81471081 ; the Natural Science Foundation of Fujian Province , China, No. 2019J01010; Xiamen Research Foundation for Science and Technology Project No. 3502Z20194037 ; and Scientific Research Foundation for Advanced Talents , Xiang’an Hospital of Xiamen University, No. PM201809170005.
Conflict-of-interest statement: There is no conflict of interest associated with the senior author or other coauthors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, MD, Doctor, Department of Endocrinology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, No. 2000 Xiang'an East Road, Xiang'an District, Xiamen 361100, Fujian Province, China.
Received: April 22, 2023
Peer-review started: April 22, 2023
First decision: July 4, 2023
Revised: July 17, 2023
Accepted: August 31, 2023
Article in press: August 31, 2023
Published online: October 6, 2023
Processing time: 156 Days and 4.3 Hours
Peer-review started: April 22, 2023
First decision: July 4, 2023
Revised: July 17, 2023
Accepted: August 31, 2023
Article in press: August 31, 2023
Published online: October 6, 2023
Processing time: 156 Days and 4.3 Hours
Core Tip
Core Tip: β-Cells are the only islet cells in the body that release insulin, and the neurotransmitter is an important factor in regulating insulin secretion. This review systematically describes the release sources of different neurotransmitters and their effects on insulin secretion. There are common mechanisms among different neurotransmitters, which mainly involve neuroanatomy and blood glucose homeostasis in vivo. There are great differences among different species. Although many specific mechanisms remain to be explored, this review provides a certain reference value and direction for subsequent research.