Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2023; 11(27): 6653-6663
Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6653
Solitary intraosseous neurofibroma in the mandible mimicking a cystic lesion: A case report and review of literature
Zheng Zhang, Xia Hong, Feng Wang, Xin Ye, You-Dan Yao, Ying Yin, Hong-Yu Yang
Zheng Zhang, Hong-Yu Yang, School of Stomatology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Zheng Zhang, Xia Hong, Feng Wang, Xin Ye, You-Dan Yao, Hong-Yu Yang, Department of Stomatology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Ying Yin, Department of Pathology, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Author contributions: Zhang Z reviewed the literature and drafted the manuscript; Yin Y provided professional opinions related to pathology; Hong X, Wang F, Ye X, Yao YD, and Yang HY were responsible for revising the manuscript for intellectual content; All authors issued final approval for the version to be submitted.
Supported by Sanming Project of Medicine in Shenzhen, No. SZSM202111012; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties, No. SZGSP008; Shenzhen Clinical Research Center for Oral Diseases, No. 20210617170745001.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Yu Yang, PhD, Chief Physician, Doctor, School of Stomatology, Zunyi Medical University, No. 6 Xuefu West Road, Xinpu New District, Zunyi 563000, Guizhou Province, China. yanghongyu@pkuszh.com
Received: July 21, 2023
Peer-review started: July 21, 2023
First decision: August 4, 2023
Revised: August 15, 2023
Accepted: August 31, 2023
Article in press: August 31, 2023
Published online: September 26, 2023
Processing time: 61 Days and 7.4 Hours
Core Tip

Core Tip: We present the case of a 37-year-old female with a solitary intraosseous neurofibroma in the right mandible, accompanied by tooth root resorption and local sensory abnormalities. Imaging revealed low-density unicysts with clear borders. The area affected by the inferior alveolar nerve canal was locally dilated, without displacement. A histological evaluation of the mass revealed spindle-shaped fibroblasts and fibroblast-like cell proliferation with a slight increase in nuclear size. Immunohistochemistry results showed positive staining for S100 and CD34 markers. Complete tumor resection and partial removal of the right inferior alveolar nerve were performed.