Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6653
Peer-review started: July 21, 2023
First decision: August 4, 2023
Revised: August 15, 2023
Accepted: August 31, 2023
Article in press: August 31, 2023
Published online: September 26, 2023
Processing time: 61 Days and 7.4 Hours
Neurofibromas are benign tumors of a neurogenic origin. If these tumors occur without any other signs of neurofibromatosis, they are classified as isolated neurofibromas. Neurofibromas in the oral cavity mostly occur within soft tissues, indicating that solitary intraosseous neurofibromas in the mandible are rare. Due to the absence of specific clinical manifestations, early diagnosis and treatment of these tumors are difficult to achieve.
A 37-year-old female patient visited our hospital due to numbness and swelling of the gums in the right lower molar area that had persisted for half a month. The patient’s overall condition and intraoral examination revealed no significant abnormalities. She was initially diagnosed with a cystic lesion in the right man
This case report discusses the key features that are useful for differentiating solitary intraosseous neurofibromas from other cystic lesions.
Core Tip: We present the case of a 37-year-old female with a solitary intraosseous neurofibroma in the right mandible, accompanied by tooth root resorption and local sensory abnormalities. Imaging revealed low-density unicysts with clear borders. The area affected by the inferior alveolar nerve canal was locally dilated, without displacement. A histological evaluation of the mass revealed spindle-shaped fibroblasts and fibroblast-like cell proliferation with a slight increase in nuclear size. Immunohistochemistry results showed positive staining for S100 and CD34 markers. Complete tumor resection and partial removal of the right inferior alveolar nerve were performed.