Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5678-5691
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5678
Relevant detection indicator of prethrombotic state in patients with primary hypertension
Jie Luo, Tuo Yang, Lan Ding, Jian-Hui Xiong, Teng Ying, Fen Xu
Jie Luo, Medical Technology Department, Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China
Tuo Yang, Inspection Department, Guangdong Zhanjiang Health School Labor Union, Zhanjiang 524094, Guangzhou Province, China
Lan Ding, Fen Xu, Department of Medical Technology, Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China
Jian-Hui Xiong, Teng Ying, Department of Cardiology, The First Affiliated Hospital of Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China
Author contributions: Luo J and Yang T concepted the study; Luo J, Xiong JH and Yang T collected the data; Luo J, Xiong JH, Ding L and Ying T contributed to the formal analysis; Luo J and Xu F contributed to the investigation; Luo J, Xu F and Xiong JH contributed to the methodology; Luo J, Ying T, Yang T and Xu F supervised the study; Ding L validated the study; Ding L and Luo J contributed to the visualization of the study; Ding L and Luo J originally drafted the manuscript; Jie Luo, Tuo Yang, Jian-Hui Xiong, Lan Ding, Teng Ying, Fen Xu reviewed and edited the manuscript.
Supported by The Science and Technology Research Project of Jiangxi Provincial Department of Education, No. GJJ2205812.
Institutional review board statement: This study has approved by the Ethical Committee of the First Affiliated Hospital of Jiangxi Medical College.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fen Xu, MD, Associate Professor, Department of Medical Technology, Jiangxi Medical College, No. 399 Zhimin Avenue, Xinzhou District, Shangrao 334000, Jiangxi Province, China. xfen202304@163.com
Received: May 19, 2023
Peer-review started: May 19, 2023
First decision: June 1, 2023
Revised: June 2, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: August 26, 2023
Processing time: 97 Days and 23 Hours
Core Tip

Core Tip: This study aimed to identify prethrombotic state-related indicators in primary hypertension (PH) patients and analyze their differences in different PH patient populations. The study found that high expression of inflammation-related indicators, vascular endothelial injury-related indicator, hemorheology-related indicators, platelet-related indicator, and coagulation function related indicators were risk factors for PH. Meanwhile, low expression of platelet and fibrinogen was also a risk factor. The study suggested that targeted interventions could be administered based on abnormal expression levels to control disease progression and reduce the risk of developing a prethrombotic state.