Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5678-5691
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5678
Relevant detection indicator of prethrombotic state in patients with primary hypertension
Jie Luo, Tuo Yang, Lan Ding, Jian-Hui Xiong, Teng Ying, Fen Xu
Jie Luo, Medical Technology Department, Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China
Tuo Yang, Inspection Department, Guangdong Zhanjiang Health School Labor Union, Zhanjiang 524094, Guangzhou Province, China
Lan Ding, Fen Xu, Department of Medical Technology, Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China
Jian-Hui Xiong, Teng Ying, Department of Cardiology, The First Affiliated Hospital of Jiangxi Medical College, Shangrao 334000, Jiangxi Province, China
Author contributions: Luo J and Yang T concepted the study; Luo J, Xiong JH and Yang T collected the data; Luo J, Xiong JH, Ding L and Ying T contributed to the formal analysis; Luo J and Xu F contributed to the investigation; Luo J, Xu F and Xiong JH contributed to the methodology; Luo J, Ying T, Yang T and Xu F supervised the study; Ding L validated the study; Ding L and Luo J contributed to the visualization of the study; Ding L and Luo J originally drafted the manuscript; Jie Luo, Tuo Yang, Jian-Hui Xiong, Lan Ding, Teng Ying, Fen Xu reviewed and edited the manuscript.
Supported by The Science and Technology Research Project of Jiangxi Provincial Department of Education, No. GJJ2205812.
Institutional review board statement: This study has approved by the Ethical Committee of the First Affiliated Hospital of Jiangxi Medical College.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fen Xu, MD, Associate Professor, Department of Medical Technology, Jiangxi Medical College, No. 399 Zhimin Avenue, Xinzhou District, Shangrao 334000, Jiangxi Province, China. xfen202304@163.com
Received: May 19, 2023
Peer-review started: May 19, 2023
First decision: June 1, 2023
Revised: June 2, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: August 26, 2023
Processing time: 97 Days and 23 Hours
ARTICLE HIGHLIGHTS
Research background

Hypertension is a common chronic disease that affects many people worldwide. Hypertension can lead to various complications, including prethrombotic state and thrombotic diseases, which pose a significant risk to patients' health.

Research motivation

The study collected data from patients with different grades of hypertension and compared them with a control group. The results showed that certain indicators, such as high-sensitivity C-reactive protein (hs-CRP), thrombomodulin (TM), hematocrit (Hct), erythrocyte sedimentation rate (ESR), P-selectin on platelet surface (CD62P), platelet (PLT), activated partial thromboplastin time (APTT), prothrombin (PT), plasma thrombin time (TT), and fibrinogen (FIB), were associated with PH progression, and their expression levels differed among the groups. High expression of some indicators, such as hs-CRP, TM, Hct, ESR, CD62P, and fibrinogen, and low expression of others, such as PLT, APTT, PT, and TT, were identified as risk factors for PH. The findings suggest that targeted interventions based on these indicators' expression levels could help control the progression of PH and reduce the risk of developing a prethrombotic state.

Research objectives

The research objectives were to investigate the relationship between these indicators and the progression of PH and identify risk factors for the development of prethrombotic state in hypertensive patients.

Research methods

This study retrospectively collected general data from patients with primary hypertension. The patients were divided into three groups based on their hypertension grade, and a control group was included. Relevant indicators of prethrombotic state were compared among the groups, including inflammation-related indicators, hemorheology-related indicators, vascular endothelial injury-related indicators, platelet-related indicators, and coagulation function-related indicators. Multivariate logistic regression models and receiver operating characteristic curve analyses were used to analyze the relationship between these indicators and PH progression. Linear correlation analysis was also performed.

Research results

The study results showed that certain indicators, including hs-CRP, TM, Hct, ESR, CD62P, PLT, APTT, PT, TT, and FIB, were associated with PH progression. The expressions of these indicators varied among hypertensive patients with different grades of hypertension and the control group. High expression of hs-CRP, TM, Hct, ESR, CD62P, and FIB, and low expression of PLT, APTT, PT, and TT, were identified as risk factors for PH.

Research conclusions

This study identified the relevant indicators associated with prethrombotic state in patients with primary hypertension. The expressions of these indicators varied among hypertensive patients with different grades of hypertension and the control group. High expression of certain indicators and low expression of others were identified as risk factors for PH progression and the development of a prethrombotic state. The study findings suggest that monitoring and controlling the expression levels of these indicators could help prevent and treat hypertensive thrombotic diseases. The results provide a laboratory basis for clinical prevention and control of hypertensive thrombotic diseases, offering valuable insights into the mechanisms underlying the development of thrombotic events in hypertensive patients.

Research perspectives

The findings of this study could pave the way for future research to investigate the mechanisms underlying the relationship between prethrombotic state and hypertension progression. Further studies could explore the efficacy of targeted interventions based on these indicators' expression levels to prevent and treat hypertensive thrombotic diseases. Additionally, future research could investigate the potential of these indicators as biomarkers for monitoring the progression of PH and predicting the development of thrombotic events in hypertensive patients. The study's results provide valuable insights into the pathophysiology of hypertensive thrombotic diseases and offer a basis for the development of personalized and effective prevention and treatment strategies for patients with PH.