Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 26, 2023; 11(12): 2684-2693
Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2684
Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2684
Analysis of oxidative stress and antioxidative potential in premature ovarian insufficiency
Kaoru Kakinuma, Toshiyuki Kakinuma, Department of Obstetrics and Gynecology, International Health and Welfare Hospital, Nasushiobara 327-2763, Japan
Author contributions: Kakinuma K and Kakinuma T contributed to the methodology, software design, validation, and formal analysis, writing-original draft preparation, writing-review and editing, visualization, supervision, and project administration.
Institutional review board statement: The present study was approved by the Institutional Review Board of the International Health and Welfare Hospital (approval No. 21-Im-075, approved on 3/22/2022).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at tokakinuma@gmail.com.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Toshiyuki Kakinuma, MD, PhD, Professor, Department of Obstetrics and Gynecology, International Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara 327-2763, Japan. tokakinuma@gmail.com
Received: January 6, 2023
Peer-review started: January 6, 2023
First decision: January 30, 2023
Revised: February 20, 2023
Accepted: March 23, 2023
Article in press: March 23, 2023
Published online: April 26, 2023
Processing time: 109 Days and 13.7 Hours
Peer-review started: January 6, 2023
First decision: January 30, 2023
Revised: February 20, 2023
Accepted: March 23, 2023
Article in press: March 23, 2023
Published online: April 26, 2023
Processing time: 109 Days and 13.7 Hours
Core Tip
Core Tip: We hypothesized that oxidative stress, suggested to be a factor in premature ovarian insufficiency (POI) and a potential POI biomarker, is likely a useful target for the treatment and early intervention for various conditions, including early POI diagnosis and infertility treatment. In this retrospective study, we discovered that oxidative stress was significantly higher in patients with POI than in healthy controls, suggesting the use of this measurement as a biomarker of POI.