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World J Clin Cases. Apr 26, 2023; 11(12): 2677-2683
Published online Apr 26, 2023. doi: 10.12998/wjcc.v11.i12.2677
Role of in vitamin D in irritable bowel syndrome
Xiao-Lan Yu, Qi-Qi Wu, Lian-Ping He, Yong-Feng Zheng
Xiao-Lan Yu, Qi-Qi Wu, Lian-Ping He, School of Medicine, Taizhou University, Jiaojiang 318000, Zhejiang Province, China
Yong-Feng Zheng, Department of Anesthesiology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, Jiangsu Province, China
Author contributions: Yu XL generated the figure and wrote the first draft; Wu QQ and Zheng YF contributed to the writing and editing of the manuscript; He LP conceptualized the topic and proofread the manuscript; All authors provided supervision and approved the submission of this minireview.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Feng Zheng, MD, Doctor, Senior Researcher, Department of Anesthesiology, Affiliated People’s Hospital of Jiangsu University, No. 8 Dianli Road, Runzhou District, Zhenjiang 212002, Jiangsu Province, China. zhengyf.163@163.com
Received: February 17, 2023
Peer-review started: February 17, 2023
First decision: March 10, 2023
Revised: March 12, 2023
Accepted: March 24, 2023
Article in press: March 24, 2023
Published online: April 26, 2023
Processing time: 67 Days and 14.1 Hours
Core Tip

Core Tip: Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder affecting 10%-22% of adults. Its development is related to the gut microbiota, and the inflammatory and immune responses triggered by the gut microbiota can lead to IBS. Vitamin D (VD) is effective in treating IBS by improving gut microbiota, immune regulation, and anti-inflammatory effects. It is necessary to carry out epidemiological studies on the relationship between VD and IBS, clinical studies on the efficacy of supplementing VD to improve IBS, and animal studies on the mechanism of VD improving IBS. This paper discussed the relationship between VD and IBS.