Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2023; 11(11): 2443-2451
Published online Apr 16, 2023. doi: 10.12998/wjcc.v11.i11.2443
Published online Apr 16, 2023. doi: 10.12998/wjcc.v11.i11.2443
Etiology analysis for term newborns with severe hyperbilirubinemia in eastern Guangdong of China
Jia-Xin Xu, Fen Lin, Yong-Hao Wu, Precision Medical Center, Chaozhou Central Hospital, Chaozhou 521021, Guangdong Province, China
Zi-Kai Chen, School of Food Engineering and Biotechnology, Hanshan Normal University, Chaozhou 521021, Guangdong Province, China
Yu-Bin Ma, Department of Pediatrics, Chaozhou Central Hospital, Chaozhou 521021, Guangdong Province, China
Li-Ye Yang, Precision Medical Lab Center, People’s Hospital of Yangjiang, Yangjiang 529500, Guangdong Province, China
Author contributions: Yang LY conceptualized and designed the study, coordinated and supervised data collection, and reviewed and revised the manuscript; Xu JX analyzed the data, drafted the initial manuscript, and revised the manuscript; Lin F collected the data, did the molecular analysis, and carried out the initial analysis; Chen ZK revised the manuscript; Wu YH and Ma YB participated in the sample and data collection and Wu YH performed the molecular analysis. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Supported by the Natural Science Foundation of Guangdong Province , No. 2016A030307035 ; Special Research Plan 2019 of Chaozhou , No. 2020xg01 ; and High-Level Development Plan of People’s Hospital of Yangjiang , No. G2020007 .
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Chaozhou Central Hospital (No. 2015001).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Ye Yang, MD, PhD, Chief Doctor, Precision Medical Lab Center, People’s Hospital of Yangjiang, No. 42 Dongshan Road, Jiangcheng District, Yangjiang 529500, Guangdong Province, China. yangleeyee@sina.com
Received: November 23, 2022
Peer-review started: November 23, 2022
First decision: February 2, 2023
Revised: February 9, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 16, 2023
Peer-review started: November 23, 2022
First decision: February 2, 2023
Revised: February 9, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: April 16, 2023
Core Tip
Core Tip: The main cause for severe hyperbilirubinemia and bilirubin encephalopathy in eastern Guangdong of China were the hemolytic disease of the newborns, glucose-6-phosphate dehydrogenase deficiency and infection. UGT1A1 gene variant was also a high-risk factor for neonatal hyperbilirubinemia.