Cao ZL, Lian BJ, Chen WY, Fang XD, Jin HY, Zhang K, Qi XP. Diagnosis and treatment of primary seminoma of the prostate: A case report and review of literature. World J Clin Cases 2023; 11(10): 2267-2275 [PMID: 37122514 DOI: 10.12998/wjcc.v11.i10.2267]
Corresponding Author of This Article
Xiao-Ping Qi, MM, Professor, Department of Urology, The 903rd PLA Hospital, Hangzhou Medical College, No. 40 Jichang Road, Hangzhou 310004, Zhejiang Province, China. qxplmd@163.com
Research Domain of This Article
Andrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zhi-Lie Cao, Bi-Jun Lian, Xu-Dong Fang, Hang-Yang Jin, Xiao-Ping Qi, Department of Urology, The 903rd PLA Hospital, Hangzhou Medical College, Hangzhou 310004, Zhejiang Province, China
Wei-Ying Chen, Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Enze Hospital, Taizhou Enze Medical Center (Group), Taizhou 318050, Zhejiang Province, China
Ke Zhang, Center for Radiation Oncology, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou 310002, Zhejiang Province, China
Author contributions: Cao ZL and Lian BJ wrote and revised the manuscript and they contributed equally to this work; Qi XP, Chen WY, and Zhang K conceived and designed the study and reviewed the manuscript; Fang XD and Jin HY collected the clinical data; all authors have read and approved the final version of the manuscript, and agree to publish the manuscript with the order of presentation of the authors.
Supported byNational Natural Science Foundation of China, No. 81472861; The Key Project of Zhejiang Province Science and Technology Plan, China, No. 2014C03048-1; and Hangzhou Municipal Commission of Health and Family Planning Science and Technology Program, No. B20210355.
Informed consent statement: The guardian of the patient provided written informed consent to publish this case report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ping Qi, MM, Professor, Department of Urology, The 903rd PLA Hospital, Hangzhou Medical College, No. 40 Jichang Road, Hangzhou 310004, Zhejiang Province, China. qxplmd@163.com
Received: November 17, 2022 Peer-review started: November 17, 2022 First decision: January 12, 2023 Revised: February 1, 2023 Accepted: March 6, 2023 Article in press: March 6, 2023 Published online: April 6, 2023 Processing time: 133 Days and 3 Hours
Core Tip
Core Tip: Primary seminoma of the prostate (PSP) is a rare type of extragonadal germ cell tumour that is easily misdiagnosed, owing to the lack of specific clinical features. To the best of our knowledge, there have been only 13 cases of PSP reported in the literature, and there is a lack of systemic research on the condition. Through this case report and literature review, we suggested that PSP should be considered in patients younger than 60 years with an enlarged prostate invading the bladder neck. This symptom occurs in 92.9% of PSP patients, and has a high sensitivity but low specificity for diagnosis. However, additional prostate biopsies may aid diagnosis, and histopathological studies are the most effective diagnostic technique. The prognoses of PSP patients are often good. While cisplatin-based chemotherapy remains to be the first-line treatment, surgery or radiotherapy may also be important options, depending on each patient’s response to chemotherapy and the location of the residual tumour.
