Case Report
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 16, 2022; 10(8): 2543-2549
Published online Mar 16, 2022. doi: 10.12998/wjcc.v10.i8.2543
Immunoglobulin G4-related disease involving multiple systems: A case report
Yu-Qiong An, Ning Ma, Yong Liu
Yu-Qiong An, Ning Ma, Heart Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
Yong Liu, Department of Ultrasound, Beijing-Shijitan Hospital, Capital Medical University, Beijing 100038, China
Author contributions: An YQ reviewed the literatures and contributed to manuscript drafting; Liu Y analyzed and interpreted the imaging findings; Liu Y and Ma N were responsible for the revision of the important intellectual contents; all authors issued the final approval for the submitted version.
Supported by Beijing Hospitals Authority Clinical Medicine Development of special funding support, No. XMLX202113; Beijing Municipal Science &Technology Commission, No. Z191100006619051; Special Fund for Open Topics of Lymph Surgery in Beijing Shijitan Hospital Affiliated to Capital Medical University, No. 2019-LB03; and Beijing Natural Science Foundation, No. 7192062.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Liu, MD, PhD, Chief Doctor, Professor, Department of Ultrasound, Beijing-Shijitan Hospital, Capital Medical University, Tieyi Road, Yangfangdian, Beijing 100038, China. liuy@bjsjth.cn
Received: August 16, 2021
Peer-review started: August 16, 2021
First decision: November 6, 2021
Revised: November 16, 2021
Accepted: January 27, 2022
Article in press: January 27, 2022
Published online: March 16, 2022
Processing time: 206 Days and 15.5 Hours
Core Tip

Core Tip: Immunoglobulin G4-related disease (IgG4-RD) can involve multiple organs and sites, such as the glands and ductal tissues. However, it is rare that a patient with more than three organs are involved at the same time, as well as the arterial lesions. In our case, we report a patient with the autoimmune inflammation, his four organs and tissues are involved, they are the aorta, pancreas, gallbladder, and submandibular gland. Meanwhile, the involved abdominal aorta and iliac artery presented as IgG4-related periarteritis. Finally, we made a comprehensive diagnosis according to the clinical histology, imaging, serology, and the response to the therapy.