Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2022; 10(7): 2194-2205
Published online Mar 6, 2022. doi: 10.12998/wjcc.v10.i7.2194
Prognostic value of neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma: A meta-analysis
Li-Peng Peng, Jie Li, Xian-Feng Li
Li-Peng Peng, Jie Li, Xian-Feng Li, Department of Orthopedic, The Second People's Hospital of Yibin, Yibin 644000, Sichuan Province, China
Author contributions: Li XF made the substantial contributions to the conception and design of the work; Peng LP and Li J searched, selected materials and extracted data; Peng LP wrote this manuscript; Li J and Li XF revised the paper carefully and also contributed to the statistical analysis; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
PRISMA 2009 Checklist statement: This systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xian-Feng Li, MD, Surgeon, Department of Orthopedic, The Second People's Hospital of Yibin, No. 96 North Street, Cuiping District, Yibin 64000, Sichuan Province, China. 2396806953@qq.com
Received: October 4, 2021
Peer-review started: October 4, 2021
First decision: November 11, 2021
Revised: November 19, 2021
Accepted: January 17, 2022
Article in press: January 17, 2022
Published online: March 6, 2022
Processing time: 148 Days and 20.2 Hours
Core Tip

Core Tip: Higher neutrophil/lymphocyte ratio (NLR) and Glasgow prognostic score (GPS) were significantly associated with poorer overall survival (OS) (P < 0.001; P < 0.001) and disease-free survival (DFS) (P < 0.001; P < 0.001). However, no significant relationship of platelet/lymphocyte ratio and lymphocyte/monocyte ratio and OS (P = 0.085; P = 0.338) and DFS (P = 0.396; P = 0.124) was observed. Higher NLR and GPS were related with worse prognosis in osteosarcoma and might serve as reliable and valuable prognostic indicators for osteosarcoma patients.